{"id":"W4399387603","doi":"10.1002/mus.28169","title":"Multicenter expanded access program for access to investigational products for amyotrophic lateral sclerosis","year":2024,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Amyotrophic lateral sclerosis; Expanded access; Clinical trial; Medicine; Investigational device exemption; Multicenter study; Physical therapy; Randomized controlled trial; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023793,0.0001523181,0.0002030566,0.000153643,0.0001124111,0.0003563183,0.0001782012,0.0001654609,0.00003490585],"category_scores_gemma":[0.0001873363,0.0001139046,0.0001266993,0.0003980181,0.0001480052,0.0003015712,0.0000981556,0.0001592141,0.000007994262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006802384,"about_ca_system_score_gemma":0.0001959683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003745684,"about_ca_topic_score_gemma":0.00002039158,"domain_scores_codex":[0.9986098,0.00002014013,0.0002924486,0.0004615127,0.0003096407,0.0003065003],"domain_scores_gemma":[0.999118,0.00008941798,0.00004339936,0.0001963015,0.0003309924,0.000221882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0009617121,0.001056333,0.002412573,0.007209855,0.0003765755,0.00001814879,0.001965576,0.00009497632,0.1581113,0.006695997,0.05077293,0.7703241],"study_design_scores_gemma":[0.006896738,0.001920564,0.6169966,0.00327003,0.0004660234,0.00001265327,0.00004197711,0.08112701,0.04611735,0.01203919,0.2303348,0.0007770601],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8588679,0.0002479096,0.003120211,0.1308452,0.001295189,0.005158266,0.00009873249,0.0003060907,0.00006052385],"genre_scores_gemma":[0.9857133,0.00001027374,0.008251143,0.002088195,0.001213987,0.001656722,0.0004460728,0.00004551508,0.0005747853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.769547,"threshold_uncertainty_score":0.4644893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1289395545020202,"score_gpt":0.3949944449040857,"score_spread":0.2660548904020655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}