{"id":"W4399389465","doi":"10.1161/jaha.123.032357","title":"Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca <sup>2+</sup> ‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability","year":2024,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Alberta; Toronto General Hospital","funders":"","keywords":"Ibrutinib; Internal medicine; AMPK; Cardioprotection; Medicine; Endocrinology; Adenosine; Protein kinase A; Pharmacology; Cardiology; Chemistry; Myocardial infarction; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002209676,0.0004539761,0.0003465424,0.0002596655,0.0001248424,0.0002821782,0.0001665868,0.0003366646,0.001056938],"category_scores_gemma":[0.0001920368,0.0002117399,0.0002188793,0.0001299757,0.0003932049,0.0002175513,0.0001676236,0.0006371348,0.0001336017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002896876,"about_ca_system_score_gemma":0.0001036765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002558508,"about_ca_topic_score_gemma":0.0002950508,"domain_scores_codex":[0.9998949,0.00001760874,0.0000133709,0.00002033128,0.0000180829,0.00003572143],"domain_scores_gemma":[0.9998474,0.00001417814,0.00007123881,0.000008902221,0.000006833321,0.00005145079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00108521,0.00004525178,0.0007292674,0.00002798958,0.000009293519,0.000100335,0.00001201867,0.00004335326,0.9967093,0.00002796565,0.00001851386,0.001191445],"study_design_scores_gemma":[0.0002416453,0.002750362,0.176045,0.0000228938,0.0001029953,0.002078348,0.0001127115,0.00200232,0.8151872,0.0002247031,0.00121593,0.00001588017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972858,0.00139701,0.0007867743,0.0000570159,0.00001530559,0.00001424184,0.00007450827,0.00003502425,0.0003341857],"genre_scores_gemma":[0.9990848,0.0002760403,0.0002733608,0.00002822814,0.00000857419,0.00001779797,0.00006106432,0.000004594882,0.0002454149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056938,"threshold_uncertainty_score":0.003535807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594068905538327,"score_gpt":0.3031152007778567,"score_spread":0.2871745117224734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}