{"id":"W4399389465","doi":"10.1161/jaha.123.032357","title":"Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca <sup>2+</sup> ‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability","year":2024,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; University of Alberta; Toronto General Hospital","funders":"","keywords":"Ibrutinib; Internal medicine; AMPK; Cardioprotection; Medicine; Endocrinology; Adenosine; Protein kinase A; Pharmacology; Cardiology; Chemistry; Myocardial infarction; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001929059,0.0001646883,0.0005859078,0.0001960654,0.0001326446,0.0001160475,0.00005812926,0.0001152244,0.000007141432],"category_scores_gemma":[0.001176887,0.0001226179,0.0002122306,0.0006416459,0.00007303464,0.0002852181,0.00005798087,0.0005879466,0.000002902094],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009742614,"about_ca_system_score_gemma":0.001370351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001501122,"about_ca_topic_score_gemma":0.00002062108,"domain_scores_codex":[0.9974813,0.0006500111,0.0005796911,0.0002577916,0.0007281359,0.0003030031],"domain_scores_gemma":[0.9988179,0.000207863,0.0003957772,0.0001859706,0.0002456382,0.0001468374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003432851,0.0003611198,0.2049553,0.0006663586,0.001341526,0.0006188625,0.00258563,0.003290576,0.7609413,0.000006595375,0.001486837,0.02031305],"study_design_scores_gemma":[0.008692626,0.001594772,0.5973879,0.0009588675,0.0005420867,0.00120187,0.0007668821,0.128635,0.2584854,0.0001485373,0.001195877,0.0003900791],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944436,0.0008767965,0.00003295641,0.003746312,0.0002052362,0.0006619786,0.000008812744,0.00002149347,0.000002832792],"genre_scores_gemma":[0.9990215,0.0001498237,0.0001213684,0.00006535796,0.0005519218,0.00001568594,0.000005500209,0.00002180037,0.00004703311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5024559,"threshold_uncertainty_score":0.9940588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594068905538327,"score_gpt":0.3031152007778567,"score_spread":0.2871745117224734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}