{"id":"W4399391946","doi":"10.21203/rs.3.rs-4381902/v1","title":"Epithelial Cell Adhesion Molecule (EpCAM)-Targeted CAR-T Cells (IMC001) in Patients with Advanced Gastric Cancer: A Phase I Dose-Escalation Trial","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Medicine; Tolerability; Epithelial cell adhesion molecule; Cancer; Gastroenterology; Internal medicine; Pharmacokinetics; Cmax; Chemotherapy; Oncology; Nuclear medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001047194,0.001473686,0.001566202,0.0003127058,0.0002696925,0.0009676352,0.0006338508,0.001100984,0.004090596],"category_scores_gemma":[0.0005406278,0.0004023227,0.001213024,0.0003764544,0.0008935371,0.0007686192,0.0003646438,0.003780382,0.0008970817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001119942,"about_ca_system_score_gemma":0.001460364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001484976,"about_ca_topic_score_gemma":0.003340475,"domain_scores_codex":[0.9997534,0.00009546701,0.000008061404,0.00004596849,0.00002195467,0.00007506431],"domain_scores_gemma":[0.999725,0.00005386819,0.00003256169,0.00002753602,0.00001461663,0.0001462951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6218519,0.05036819,0.006347003,0.001128331,0.00198712,0.0003126055,0.0003975851,0.006525421,0.04071732,0.0009585461,0.01809079,0.2513152],"study_design_scores_gemma":[0.6998736,0.2735643,0.01065417,0.00005449944,0.0009106052,0.0002408594,0.00011258,0.002931361,0.005305031,0.000519056,0.005791127,0.00004274611],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911573,0.002390377,0.0004400052,0.00124278,0.0001933118,0.0008785157,0.0009646426,0.0001368693,0.002596176],"genre_scores_gemma":[0.9817139,0.00285997,0.002092724,0.001699604,0.0002030667,0.001419731,0.003124852,0.00006912286,0.006817076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004090596,"threshold_uncertainty_score":0.01368445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03403510047983695,"score_gpt":0.3872638101725909,"score_spread":0.353228709692754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}