{"id":"W4399394226","doi":"10.1200/jco.2024.42.16_suppl.tps4619","title":"A phase 2/3 study of Bicycle toxin conjugate BT8009 targeting nectin-4 in patients with locally advanced or metastatic urothelial cancer (la/mUC): Duravelo-2.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Urinary and Genital Oncology Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Urothelial cancer; Medicine; Cancer; Conjugate; Toxin; Cancer research; Internal medicine; Oncology; Bladder cancer; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001609912,0.00192182,0.001784158,0.0003673379,0.0004289486,0.0009973561,0.0009606919,0.00142008,0.006744923],"category_scores_gemma":[0.0009902833,0.0005885841,0.001279002,0.0003714793,0.0007845807,0.0009578089,0.0005339155,0.003315456,0.00154148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001105514,"about_ca_system_score_gemma":0.001892036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381834,"about_ca_topic_score_gemma":0.003587102,"domain_scores_codex":[0.9996256,0.0001591442,0.00001360815,0.00007218884,0.00003270905,0.00009682042],"domain_scores_gemma":[0.9993735,0.00006920833,0.0001190683,0.00005244885,0.00004291153,0.000342922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7207896,0.1041268,0.0101278,0.001645924,0.001370159,0.0005064812,0.0004784932,0.003095442,0.04823807,0.0004507298,0.01025453,0.09891594],"study_design_scores_gemma":[0.5155635,0.4616952,0.0120051,0.00006156779,0.0005014522,0.00044568,0.0001117983,0.001118525,0.002896395,0.00030446,0.005259444,0.00003677095],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800867,0.002205394,0.0009525882,0.000884827,0.0001969455,0.008824654,0.004146142,0.0002183317,0.00248434],"genre_scores_gemma":[0.9647313,0.002498139,0.003844182,0.002413903,0.0002535494,0.01217877,0.007884735,0.00009840665,0.006096952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006744923,"threshold_uncertainty_score":0.02256399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07983621505020365,"score_gpt":0.4829374889075808,"score_spread":0.4031012738573771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}