{"id":"W4399394226","doi":"10.1200/jco.2024.42.16_suppl.tps4619","title":"A phase 2/3 study of Bicycle toxin conjugate BT8009 targeting nectin-4 in patients with locally advanced or metastatic urothelial cancer (la/mUC): Duravelo-2.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Urinary and Genital Oncology Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Urothelial cancer; Medicine; Cancer; Conjugate; Toxin; Cancer research; Internal medicine; Oncology; Bladder cancer; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002464966,0.0002096671,0.001954516,0.0002397148,0.00004430152,0.000007857389,0.0001400921,0.000160448,0.000140843],"category_scores_gemma":[0.003517765,0.0001214062,0.000215333,0.000398102,0.0002941835,0.0001740677,0.00007315059,0.001105103,0.000005680145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409792,"about_ca_system_score_gemma":0.001969413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003414416,"about_ca_topic_score_gemma":0.0002976437,"domain_scores_codex":[0.9956791,0.0007576775,0.002606372,0.0002827046,0.0003908633,0.000283293],"domain_scores_gemma":[0.9938283,0.004317321,0.001057299,0.0001268779,0.0004598843,0.0002103412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1930534,0.06303131,0.4297616,0.0003631158,0.004286481,0.01221828,0.003420719,0.0003367834,0.0003667851,0.00002881172,0.001132858,0.2919998],"study_design_scores_gemma":[0.1246426,0.3797387,0.473956,0.0008236271,0.002380815,0.0002708073,0.004529964,0.0002857747,0.0001947389,0.0001357071,0.01273179,0.0003094383],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995065,0.0007219146,0.00005966867,0.001937463,0.001001811,0.0007272129,0.00001085387,0.00001252631,0.0004636017],"genre_scores_gemma":[0.9971452,0.0002016825,0.00149953,0.0005176374,0.0003108455,0.00003560247,0.000001206655,0.00002570423,0.0002625907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3167073,"threshold_uncertainty_score":0.4950803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07983621505020365,"score_gpt":0.4829374889075808,"score_spread":0.4031012738573771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}