{"id":"W4399394448","doi":"10.1371/journal.pone.0303450","title":"Phase 1, randomized, rater and participant blinded placebo-controlled study of the safety, reactogenicity, tolerability and immunogenicity of H1N1 influenza vaccine delivered by VX-103 (a MIMIX microneedle patch [MAP] system) in healthy adults","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Social Innovation; Sonaca (Canada)","funders":"","keywords":"Reactogenicity; Medicine; Tolerability; Placebo; Randomized controlled trial; Adverse effect; Influenza vaccine; Internal medicine; Seroconversion; Immunogenicity; Vaccination; Immunology; Immune system; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005657485,0.002793233,0.004388237,0.0007261082,0.001141826,0.001282297,0.001826282,0.002765519,0.007912103],"category_scores_gemma":[0.00582347,0.001379188,0.001291557,0.000829343,0.002095695,0.001379838,0.0005128967,0.002694011,0.00113766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001710681,"about_ca_system_score_gemma":0.004662329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002865485,"about_ca_topic_score_gemma":0.007254315,"domain_scores_codex":[0.9974492,0.00135748,0.0001470534,0.0004618329,0.0002793586,0.0003050247],"domain_scores_gemma":[0.9967866,0.000808298,0.0009181701,0.0003141082,0.000502022,0.0006708392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.975388,0.01417832,0.000469082,0.000546255,0.0004615528,0.00002780051,0.00009688472,0.0002209027,0.002367868,0.00009963259,0.0006973728,0.005446472],"study_design_scores_gemma":[0.9048976,0.09254634,0.001144444,0.0000232805,0.0001907741,0.00001799953,0.0000191946,0.0002128525,0.0003198104,0.00009849631,0.0005176842,0.00001143627],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.904081,0.002833656,0.003127252,0.0007987385,0.0008240276,0.08202004,0.003434377,0.0003103595,0.002570426],"genre_scores_gemma":[0.871725,0.002812464,0.009412654,0.001954189,0.0009002635,0.1042569,0.001805174,0.00008494955,0.007048404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007912103,"threshold_uncertainty_score":0.02991998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1082271674489081,"score_gpt":0.3919088707621904,"score_spread":0.2836817033132823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}