{"id":"W4399394556","doi":"10.1200/jco.2024.42.16_suppl.5089","title":"A phase II trial of enzalutamide (Enz) with 5-alpha reductase inhibitors (5-ARI) as an androgen deprivation therapy (ADT)–sparing approach for older men with castration-sensitive prostate cancer (CSPC).","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Enzalutamide; Medicine; Androgen deprivation therapy; Prostate cancer; Castration; Internal medicine; Oncology; Androgen; Clinical trial; Androgen receptor; Urology; Cancer; Gynecology; Hormone","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001641828,0.001420005,0.001378345,0.0004007723,0.0004120311,0.0008657904,0.0008764789,0.001421879,0.004753169],"category_scores_gemma":[0.000836763,0.000608652,0.00117119,0.0003297712,0.0009059203,0.0008905738,0.0003614317,0.003005386,0.0008972625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006440041,"about_ca_system_score_gemma":0.001403271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066191,"about_ca_topic_score_gemma":0.00288404,"domain_scores_codex":[0.9996384,0.0001850483,0.00001851621,0.00006243602,0.00002634946,0.0000693183],"domain_scores_gemma":[0.9992813,0.0001047668,0.0001130497,0.00004792281,0.0000468351,0.0004061507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8761407,0.05970585,0.003016211,0.0006140172,0.0009695933,0.0001527816,0.0002171871,0.001266113,0.01519274,0.0002775421,0.00272171,0.03972561],"study_design_scores_gemma":[0.7530991,0.2389842,0.004344872,0.0000247178,0.0002607593,0.0001046739,0.0000389097,0.0007311649,0.000908734,0.0001497219,0.001336393,0.00001669472],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875088,0.002223718,0.0006824185,0.0006479056,0.0002278663,0.004745041,0.001275832,0.0001198058,0.00256851],"genre_scores_gemma":[0.9848541,0.00167192,0.001989482,0.001445325,0.0002264772,0.004055816,0.002461301,0.00002410374,0.003271419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004753169,"threshold_uncertainty_score":0.01590097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1221064687243994,"score_gpt":0.4901304543807966,"score_spread":0.3680239856563973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}