{"id":"W4399394761","doi":"10.1200/jco.2024.42.16_suppl.tps5123","title":"Phase III, double-blind, placebo-controlled, 2-cohort, randomized study of saruparib (AZD5305) in combination with new hormonal agents in patients with metastatic castration-sensitive prostate cancer with and without homologous recombination repair mutation (EvoPAR-Prostate01).","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Prostate cancer; Placebo; Homologous recombination; Oncology; Hormonal therapy; Internal medicine; Cancer; Hormone; Cohort; Prostate; Urology; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003419383,0.003515452,0.004582637,0.0006648996,0.000939746,0.001553929,0.001747297,0.00300073,0.01208568],"category_scores_gemma":[0.002584072,0.001718863,0.002536432,0.0006607742,0.002302596,0.002116228,0.0007648857,0.005307017,0.002475136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001062899,"about_ca_system_score_gemma":0.002435969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247976,"about_ca_topic_score_gemma":0.003239206,"domain_scores_codex":[0.9988702,0.0005242262,0.00005240394,0.0002736034,0.00009313218,0.0001864731],"domain_scores_gemma":[0.9982495,0.0002925764,0.0003782176,0.0001986828,0.0001678858,0.0007131925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9719042,0.01895065,0.0006142232,0.0003070932,0.0006702601,0.00002770454,0.00004939477,0.000162345,0.001970952,0.00005706303,0.0008039517,0.004482193],"study_design_scores_gemma":[0.9429663,0.05495504,0.001162966,0.0000107484,0.0001907949,0.0000169252,0.00001319943,0.0001294062,0.0001537628,0.00006411847,0.0003258406,0.00001093121],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691461,0.003514409,0.001503612,0.001200295,0.001100595,0.01594517,0.004044967,0.0003851574,0.003159707],"genre_scores_gemma":[0.9567275,0.002733344,0.004442238,0.003515953,0.001195588,0.01993745,0.004145163,0.0000976892,0.007204917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01208568,"threshold_uncertainty_score":0.04043061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0818484846970013,"score_gpt":0.4552824990079004,"score_spread":0.3734340143108991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}