{"id":"W4399427972","doi":"10.1016/j.jbc.2024.107455","title":"Discovery of an antivirulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin-1 production","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; McMaster University","keywords":"Staphylococcus aureus; Toxin; Microbiology; Toxic shock syndrome; Shock (circulatory); Component (thermodynamics); Chemistry; Biology; Bacteria; Medicine; Physics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009637635,0.0004478381,0.0003723117,0.0003574904,0.0001164066,0.0001897663,0.0002179225,0.0003014978,0.0009915517],"category_scores_gemma":[0.00008240368,0.0001390957,0.0002588234,0.0001736964,0.0001179244,0.0001237505,0.0001491913,0.0003801367,0.0002365804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935351,"about_ca_system_score_gemma":0.0002137188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004013582,"about_ca_topic_score_gemma":0.0008540042,"domain_scores_codex":[0.999945,0.000008296442,0.000004430342,0.000009889225,0.00001668805,0.00001566703],"domain_scores_gemma":[0.9999623,0.000006547323,0.000008154167,0.000002111651,0.00000878627,0.00001208948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001352036,0.000122495,0.0001550556,0.00007778891,0.00001000161,0.0001188182,0.000008526912,0.0003301383,0.9932916,0.0000717436,0.00009693911,0.005581673],"study_design_scores_gemma":[0.0002956532,0.005277706,0.004374955,0.00002499829,0.00008245649,0.0007602147,0.00003248514,0.002474759,0.9786389,0.00007917212,0.007940089,0.0000186248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844071,0.005985621,0.005091182,0.0002655522,0.00007246304,0.000219664,0.0006195047,0.0001585552,0.003180407],"genre_scores_gemma":[0.9848802,0.005081876,0.005861393,0.0002309497,0.00002706409,0.0000930073,0.001148908,0.00001898715,0.002657631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009915517,"threshold_uncertainty_score":0.003317058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267039904106005,"score_gpt":0.2759621274500141,"score_spread":0.253291728408954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}