{"id":"W4399435700","doi":"10.1038/s41467-024-49230-z","title":"A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Commission; Fondation du cancer du sein du Québec; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; McGill University","keywords":"Mechanotransduction; Breast cancer; Cell biology; Biology; Cancer research; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006136735,0.0001765023,0.0001069433,0.00009622364,0.0001445346,0.0001594754,0.0001203535,0.000118793,0.0007005028],"category_scores_gemma":[0.00005358558,0.000107239,0.000130144,0.00004704893,0.0001669747,0.0001516825,0.0002617158,0.0003109258,0.0001559198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002109303,"about_ca_system_score_gemma":0.0001612059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002268605,"about_ca_topic_score_gemma":0.0005924016,"domain_scores_codex":[0.9999474,0.000004696652,0.000001921075,0.00001297529,0.00001485165,0.00001812905],"domain_scores_gemma":[0.9999477,0.000004867022,0.0000174276,0.000004360262,0.000005736624,0.00002001666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002588868,0.000005574928,0.0002260844,0.000007861916,0.000001066096,0.00003139609,0.000008649469,0.0000480294,0.9990942,0.00008463786,0.00001955653,0.0004470659],"study_design_scores_gemma":[0.00001535805,0.0001384338,0.01246834,0.000003998709,0.000005502574,0.0001842413,0.00005869765,0.003073801,0.9827947,0.0001190559,0.001133849,0.000003970915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969983,0.0001635888,0.002054038,0.00005113542,0.00000581253,0.000005206484,0.0000564169,0.00005419995,0.00061143],"genre_scores_gemma":[0.9983187,0.00008549794,0.0007044125,0.0000118939,0.000003376923,0.000008741665,0.00007422581,0.000006468163,0.0007868005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007005028,"threshold_uncertainty_score":0.002343416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750795082644728,"score_gpt":0.2866264485445058,"score_spread":0.2691184977180585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}