{"id":"W4399437865","doi":"10.1038/s41593-024-01666-8","title":"Developmental origin of oligodendrocytes determines their function in the adult brain","year":2024,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute on Aging; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Svenska Läkaresällskapet; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; LouLou Foundation; Svenska Sällskapet för Medicinsk Forskning; National Centre for the Replacement, Refinement and Reduction of Animals in Research; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Karolinska Institutet; European Commission; Hjärnfonden; Medical Research Council; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Göran Gustafssons Stiftelser; Multiple Sclerosis Society; Wellcome Trust","keywords":"Oligodendrocyte; Biology; Neuroscience; Forebrain; Fate mapping; Lineage (genetic); Embryonic stem cell; OLIG2; Central nervous system; Progenitor cell; Myelin; Stem cell; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287439,0.0001335453,0.0001506053,0.0002874942,0.0001589851,0.000523452,0.0001537448,0.0001344274,0.0002736888],"category_scores_gemma":[0.0001652516,0.0001004552,0.00006822909,0.0001150152,0.000321699,0.0002176834,0.0002953905,0.0003094477,0.0001890365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001837874,"about_ca_system_score_gemma":0.0002651122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007239719,"about_ca_topic_score_gemma":0.001429357,"domain_scores_codex":[0.9998816,0.00001258049,0.00001189653,0.00002795168,0.00004227099,0.00002355712],"domain_scores_gemma":[0.9998502,0.00001717846,0.00005557938,0.0000131369,0.00002514974,0.00003884346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003622667,0.000004182162,0.001562705,0.00001466213,0.000002144316,0.00005554959,0.0000420205,0.00003589319,0.9948981,0.0005073626,0.00001654323,0.002824588],"study_design_scores_gemma":[0.000008539234,0.0001974494,0.07084314,0.00003305544,0.00003401638,0.001824248,0.0003022291,0.0009744855,0.9154586,0.001272216,0.009035975,0.00001608917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901628,0.002430776,0.00507506,0.00005428687,0.000008767666,0.000007889384,0.0001404215,0.00004625087,0.002073837],"genre_scores_gemma":[0.9935392,0.001801949,0.002790966,0.00003722745,0.000007213155,0.000008943172,0.0001827921,0.0000209834,0.001610792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007239719,"threshold_uncertainty_score":0.001439512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772206673426301,"score_gpt":0.2768340387436795,"score_spread":0.2491119720094165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}