{"id":"W4399438808","doi":"10.1161/circgen.123.004448","title":"Novel Multiplexed Plasma Biomarker Panel Has Diagnostic and Prognostic Potential in Children With Hypertrophic Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Invention for Innovation; Great Ormond Street Hospital Charity; University College London; National Institute for Health and Care Research; Action Medical Research; Medical Research Council; Barts Charity; Great Ormond Street Hospital for Children; British Heart Foundation; LifeArc","keywords":"Hypertrophic cardiomyopathy; Biomarker; Medicine; Internal medicine; Proteomics; Oncology; Bioinformatics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004003578,0.0002173643,0.0004524411,0.0003430855,0.0001013723,0.00005593885,0.00003529791,0.0001288428,0.00002411231],"category_scores_gemma":[0.0002513739,0.000145127,0.00006029499,0.0002537083,0.0001974223,0.00008025912,0.00004413592,0.0002006459,0.000005753869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005456419,"about_ca_system_score_gemma":0.00007853779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001298351,"about_ca_topic_score_gemma":0.00000419562,"domain_scores_codex":[0.9985543,0.00004241658,0.0003843652,0.0005162758,0.0002926695,0.0002098978],"domain_scores_gemma":[0.9991769,0.0003498729,0.00004915517,0.0001899731,0.00006026879,0.0001738337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002797375,0.0000448249,0.660747,0.0001626588,0.0001929821,0.00004274831,0.0006795272,0.002229061,0.2429017,0.00002496373,0.00007026685,0.0926245],"study_design_scores_gemma":[0.003230372,0.0001642602,0.8889859,0.001023882,0.000378481,0.001505801,0.00007766821,0.1042357,0.00002070229,0.00004497308,0.0001737509,0.0001584769],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797559,0.01191359,0.006308624,0.0007436775,0.000252649,0.0009012796,0.00001333618,0.00005683751,0.00005409478],"genre_scores_gemma":[0.9977591,0.0008230337,0.0008016371,0.00007400104,0.0003528131,0.00002287438,0.00009939585,0.00003892035,0.00002822718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.242881,"threshold_uncertainty_score":0.5918108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302122756217247,"score_gpt":0.2473088959641846,"score_spread":0.2142876684020122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}