{"id":"W4399438808","doi":"10.1161/circgen.123.004448","title":"Novel Multiplexed Plasma Biomarker Panel Has Diagnostic and Prognostic Potential in Children With Hypertrophic Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Invention for Innovation; Great Ormond Street Hospital Charity; University College London; National Institute for Health and Care Research; Action Medical Research; Medical Research Council; Barts Charity; Great Ormond Street Hospital for Children; British Heart Foundation; LifeArc","keywords":"Hypertrophic cardiomyopathy; Biomarker; Medicine; Internal medicine; Proteomics; Oncology; Bioinformatics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118612,0.0004432795,0.000475723,0.0006609465,0.0001915142,0.0004141207,0.0002464548,0.0005007142,0.0004960262],"category_scores_gemma":[0.002654458,0.0002026072,0.0002019393,0.0005725605,0.0002411843,0.0003225718,0.0003415993,0.0005000472,0.0001726549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003353073,"about_ca_system_score_gemma":0.0002606053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000575294,"about_ca_topic_score_gemma":0.0006774453,"domain_scores_codex":[0.9994705,0.0001760896,0.00004536196,0.0001330818,0.0001252245,0.00004965113],"domain_scores_gemma":[0.9985305,0.0006520494,0.0004323834,0.0000586981,0.0002013447,0.0001251246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004288008,0.00005002616,0.9765325,0.00003527522,0.00006106945,0.0003928548,0.000086272,0.0006208543,0.007491776,0.00004898741,0.0004304561,0.0138212],"study_design_scores_gemma":[0.00005603976,0.0008244999,0.9714475,0.00004190193,0.0001379148,0.005025064,0.0001429168,0.009453356,0.0111636,0.0002045479,0.001482071,0.00002069874],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970084,0.0009901141,0.001288142,0.00009622458,0.000009642644,0.00001358402,0.0002862411,0.00003581307,0.0002718407],"genre_scores_gemma":[0.9954199,0.000207764,0.003819729,0.00006426931,0.00001565381,0.00002113437,0.0003801076,0.000005210997,0.00006632873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118612,"threshold_uncertainty_score":0.00591588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302122756217247,"score_gpt":0.2473088959641846,"score_spread":0.2142876684020122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}