{"id":"W4399443237","doi":"10.1101/2024.06.06.597804","title":"Hemoglobin Rothschild: Structural Rationalization of Decreased O <sub>2</sub> Affinity as a Consequence of a β37(C3)Trp→Arg Mutation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Rationalization (economics); Rothschild; Genetics; Mutation; Economics; Biology; Political science; Microeconomics; Gene; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003434721,0.0004599011,0.0004777769,0.0002139514,0.0000839147,0.00006543211,0.0002929922,0.0006947148,0.00002440999],"category_scores_gemma":[0.0005586161,0.0004905203,0.0002282686,0.0004206307,0.0002207188,0.00001500812,0.0003069523,0.0003696438,0.00001156765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001041038,"about_ca_system_score_gemma":0.001467657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007845446,"about_ca_topic_score_gemma":0.000008245843,"domain_scores_codex":[0.9975647,0.000178838,0.0007185453,0.0008464495,0.0003994014,0.0002921069],"domain_scores_gemma":[0.9975601,0.00003484016,0.0006216011,0.0007745549,0.000854971,0.0001539778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001647824,0.00003962748,0.0007478151,0.0005628092,0.0002114579,0.00002358344,0.0000103856,0.0005321071,0.9967466,0.0007941884,0.0001475939,0.00001906275],"study_design_scores_gemma":[0.0005067341,0.0001583453,0.009266823,0.0002635855,0.0001759665,8.102429e-7,0.000004112162,0.0003862614,0.9884651,0.000126084,0.0002099207,0.000436238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935214,0.001455489,0.002856991,0.00006512523,0.0007621782,0.0007168397,0.0005319346,0.00007166545,0.00001838979],"genre_scores_gemma":[0.9972588,0.0001881185,0.00189178,0.0001201607,0.0003493276,0.00007981519,0.00003322769,0.00007667945,0.000002107754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008519007,"threshold_uncertainty_score":0.9997547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006632007780021315,"score_gpt":0.2200709467571915,"score_spread":0.2134389389771701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}