{"id":"W4399446748","doi":"10.1016/j.bbagrm.2024.195045","title":"HBO1, a MYSTerious KAT and its links to cancer","year":2024,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Biology; Histone methyltransferase; Histone H4; Cancer epigenetics; Histone H3; Cancer research; Histone; Histone H2A; Chromatin remodeling; Cell biology; Histone methylation; Acetylation; Genetics; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000653652,0.001004133,0.001188649,0.001392212,0.0003245618,0.001283829,0.0008725591,0.001479218,0.002825059],"category_scores_gemma":[0.0007301126,0.0003718297,0.0002979286,0.001846632,0.001009462,0.001476178,0.0007993893,0.002828718,0.002421858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008474289,"about_ca_system_score_gemma":0.00108753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001167498,"about_ca_topic_score_gemma":0.002231593,"domain_scores_codex":[0.999871,0.00001819223,0.00001454176,0.00002727063,0.00004991629,0.0000190408],"domain_scores_gemma":[0.9998155,0.00008346101,0.00002279337,0.000007180288,0.00004475683,0.00002628901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002381338,0.00007346684,0.0002107549,0.009468995,0.00008397364,0.000273939,0.00005566689,0.0005053275,0.0024469,0.01180386,0.1000258,0.8748133],"study_design_scores_gemma":[0.00002823987,0.00004663948,0.0003543031,0.0008334182,0.00004689728,0.0004871593,0.00003161448,0.00005889455,0.000428078,0.003234284,0.9944379,0.00001246179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005139342,0.998625,0.00008294886,0.0003128929,0.0003599408,0.000001814813,0.00001444497,0.000004341847,0.0005472568],"genre_scores_gemma":[0.0005042633,0.9977011,0.0001038054,0.0003513905,0.0004335529,0.000004832401,0.00004032429,0.00000149683,0.0008592108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002825059,"threshold_uncertainty_score":0.009450734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374841787841502,"score_gpt":0.3525146347418005,"score_spread":0.3187662168633855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}