{"id":"W4399452320","doi":"10.1200/jco.2024.42.17_suppl.lba105","title":"Results from the randomized phase 3 DREAMM-8 study of belantamab mafodotin plus pomalidomide and dexamethasone (BPd) vs pomalidomide plus bortezomib and dexamethasone (PVd) in relapsed/refractory multiple myeloma (RRMM).","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"GlaxoSmithKline","keywords":"Medicine; Pomalidomide; Lenalidomide; Internal medicine; Dexamethasone; Clinical endpoint; Bortezomib; Multiple myeloma; Interim analysis; Refractory (planetary science); Randomized controlled trial; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004542695,0.001603821,0.002630231,0.0004141568,0.000578934,0.001408637,0.001417954,0.002006757,0.009412006],"category_scores_gemma":[0.003522248,0.0008177182,0.002528555,0.0004395526,0.001127413,0.001473721,0.0007108872,0.005314002,0.001555403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001224649,"about_ca_system_score_gemma":0.001807813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009470274,"about_ca_topic_score_gemma":0.002728953,"domain_scores_codex":[0.9983628,0.001043479,0.00009750691,0.0002207225,0.0001207079,0.0001547913],"domain_scores_gemma":[0.9975744,0.0007274276,0.000619998,0.0001726648,0.0001405915,0.0007649036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9767993,0.007360347,0.0007506866,0.0003565212,0.00109352,0.00003336173,0.00005457932,0.0003358572,0.001908042,0.00007874593,0.001520259,0.009708744],"study_design_scores_gemma":[0.9149455,0.07979345,0.002486906,0.00003855914,0.0007219355,0.00006397017,0.00003046412,0.0002798807,0.0003634946,0.0002037037,0.001054655,0.00001737867],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684313,0.005772942,0.001134455,0.001816698,0.0007822523,0.01055375,0.006641184,0.0002390799,0.004628367],"genre_scores_gemma":[0.9756964,0.002141343,0.002786361,0.002223,0.0003924814,0.008374589,0.004810285,0.00007508139,0.003500441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009412006,"threshold_uncertainty_score":0.03148633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137348301454609,"score_gpt":0.4558201448098906,"score_spread":0.3420853146644298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}