{"id":"W4399452333","doi":"10.1200/jco.2024.42.17_suppl.lba5002","title":"A randomized, double-blind, placebo-controlled trial of metformin in reducing progression among men on expectant management for low-risk prostate cancer: The MAST (Metformin Active Surveillance Trial) study.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Manitoba; St. Joseph’s Healthcare Hamilton; McMaster University; Queen's University; McGill University Health Centre; Health Sciences Centre; Ottawa Hospital; University Health Network; CancerCare Manitoba; University of Toronto; Western University; Hôpital Fleurimont; Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; Dalhousie University","funders":"","keywords":"Medicine; Metformin; Prostate cancer; Tolerability; Prostatectomy; Clinical endpoint; Prostate; Internal medicine; Placebo; Prostate-specific antigen; Randomized controlled trial; Cancer; Oncology; Urology; Gynecology; Adverse effect; Pathology; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00169797,0.001575586,0.002936563,0.0006043415,0.0006054992,0.0009552126,0.0009739826,0.002184281,0.006594846],"category_scores_gemma":[0.001665884,0.0007453606,0.001367301,0.0004191823,0.001277474,0.0009296741,0.0004617212,0.002260349,0.0007326039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007970158,"about_ca_system_score_gemma":0.001574103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002363186,"about_ca_topic_score_gemma":0.006032347,"domain_scores_codex":[0.9994592,0.0003006679,0.00002890297,0.00008459598,0.00003775912,0.00008880645],"domain_scores_gemma":[0.9991406,0.0001615881,0.0002028483,0.00005719945,0.00006132931,0.0003763334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9873001,0.005676755,0.0003084419,0.0003150968,0.0002957309,0.00001638564,0.00002147285,0.00008162507,0.0008893719,0.00004828516,0.0003764046,0.004670287],"study_design_scores_gemma":[0.96659,0.03166575,0.001074192,0.00001696132,0.0001663483,0.000007917941,0.00001104799,0.0001409326,0.00009157128,0.00004200131,0.0001871206,0.000005984891],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844827,0.004525835,0.0004119723,0.000786345,0.0008344878,0.005784577,0.001104492,0.0001258274,0.001943539],"genre_scores_gemma":[0.9832343,0.002796645,0.001567356,0.001308146,0.0007850603,0.005955117,0.0009268312,0.00001679346,0.003409646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006594846,"threshold_uncertainty_score":0.02206194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05133550329338653,"score_gpt":0.4349183717614382,"score_spread":0.3835828684680517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}