{"id":"W4399457828","doi":"10.1038/s41467-024-49234-9","title":"FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Congressionally Directed Medical Research Programs; CIHR Skin Research Training Centre; National Cancer Institute; Cancer Council NSW; Cancer Council South Australia; Canadian Institutes of Health Research; Marshfield Clinic Research Foundation; Department of Health, State Government of Victoria; National Breast Cancer Foundation; Yuhan; Department of Health and Human Services, State Government of Victoria; University of Massachusetts Boston; Movember Foundation; Government of Canada; National Institutes of Health; U.S. Department of Health and Human Services; Australian Government; U.S. Department of Defense","keywords":"Reprogramming; Lineage (genetic); Prostate cancer; Biology; Cancer; Prostate; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645734,0.0001649921,0.0001492042,0.0002072632,0.0002443889,0.0003777506,0.0002015924,0.0002006291,0.001874068],"category_scores_gemma":[0.0001149648,0.0001128506,0.0002220712,0.000158149,0.0002314396,0.0002778961,0.0004521583,0.0003417712,0.0004292387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004073251,"about_ca_system_score_gemma":0.0002731039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006816324,"about_ca_topic_score_gemma":0.001835364,"domain_scores_codex":[0.9998813,0.00001404826,0.000004095151,0.00003165213,0.00003617001,0.00003284848],"domain_scores_gemma":[0.9999459,0.000004654974,0.000009339804,0.000008399929,0.000007940888,0.00002382447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000100598,0.00001577746,0.001960586,0.0000493189,0.000009989324,0.0001259118,0.00004460059,0.0001575574,0.9914591,0.0008419998,0.0002603164,0.004974109],"study_design_scores_gemma":[0.00003343796,0.0002106818,0.04870332,0.00002577853,0.00003349761,0.001168973,0.0002593268,0.004331599,0.9106014,0.001089081,0.03352258,0.00002026077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846917,0.004384237,0.004945083,0.0003470766,0.00006728403,0.00001597621,0.0002901047,0.00019037,0.005068212],"genre_scores_gemma":[0.9938267,0.0007440918,0.001074586,0.0001006453,0.00001238176,0.00001183044,0.0002228072,0.00002481078,0.003982185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874068,"threshold_uncertainty_score":0.006269336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075208553738794,"score_gpt":0.3260561319377542,"score_spread":0.3053040464003663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}