{"id":"W4399481218","doi":"10.1200/jco.2024.42.16_suppl.7046","title":"Evaluating CR as a surrogate endpoint for PFS in R/R chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): A meta-analysis of randomized controlled trials (RCT).","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"EVERSANA (Canada)","funders":"","keywords":"Medicine; Chronic lymphocytic leukemia; Randomized controlled trial; Oncology; Internal medicine; Clinical endpoint; Lymphoma; Surrogate endpoint; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.03335395,0.002662903,0.01401989,0.004483266,0.0004952531,0.002500551,0.001523013,0.002397967,0.00305172],"category_scores_gemma":[0.06263396,0.001195482,0.04544663,0.004542322,0.0007442095,0.002096365,0.001465494,0.002933373,0.0003335035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002157071,"about_ca_system_score_gemma":0.002614325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003697526,"about_ca_topic_score_gemma":0.00741573,"domain_scores_codex":[0.970838,0.02172642,0.004463122,0.001468685,0.001092214,0.0004116478],"domain_scores_gemma":[0.9615397,0.03137302,0.004346304,0.001273982,0.001154931,0.0003120065],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007667568,0.00005226325,0.003691623,0.152744,0.8255171,0.00009947801,0.00005815725,0.0008994953,0.0002692169,0.000238634,0.0005108817,0.008251458],"study_design_scores_gemma":[0.003415487,0.0006024767,0.001951326,0.006523979,0.9853781,0.00006195232,0.00002651143,0.0004798258,0.0001219248,0.0003690169,0.001051872,0.00001749994],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02447231,0.965076,0.004240226,0.0008301273,0.0005057005,0.00233572,0.001604559,0.0001082581,0.000827014],"genre_scores_gemma":[0.6541338,0.3182254,0.01362581,0.00252084,0.0005074269,0.007703493,0.002336896,0.00008478491,0.0008615083],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9859801,"threshold_uncertainty_score":0.1763946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4792055089312228,"score_gpt":0.5875569842723763,"score_spread":0.1083514753411536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}