{"id":"W4399481993","doi":"10.1136/annrheumdis-2024-eular.1406","title":"POS0322 GUSELKUMAB BINDING TO CD64+ IL-23–PRODUCING MYELOID CELLS ENHANCES POTENCY FOR NEUTRALIZING IL-23 SIGNALING","year":2024,"lang":"en","type":"article","venue":"","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Potency; Immunology; Chemistry; Medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819433,0.000341591,0.000319814,0.0001424397,0.0001733366,0.0004169306,0.0002268588,0.0003511374,0.004871891],"category_scores_gemma":[0.0001585555,0.0001031745,0.0002354248,0.0001434934,0.0001799844,0.0001512423,0.0001402583,0.001021666,0.001448484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002325908,"about_ca_system_score_gemma":0.0002107166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004522963,"about_ca_topic_score_gemma":0.0005816103,"domain_scores_codex":[0.9997948,0.00004314526,0.00001814933,0.00003218517,0.00004405606,0.0000676873],"domain_scores_gemma":[0.9998944,0.00002387474,0.00001438946,0.00001505373,0.00001328145,0.00003908266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007982159,0.0003146515,0.0002746508,0.0000468894,0.000007635753,0.00003370199,0.00001347449,0.0001445934,0.995845,0.00004562781,0.0003073066,0.002168196],"study_design_scores_gemma":[0.00009463028,0.00252361,0.002618367,0.000005288498,0.00001867348,0.0001820166,0.00002046719,0.0009736736,0.991787,0.00002453421,0.001746996,0.000004743138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956944,0.0006458116,0.001054532,0.00009683179,0.00006089738,0.0000510927,0.0004008463,0.00008680343,0.001908856],"genre_scores_gemma":[0.9954601,0.0003269433,0.001442153,0.000137773,0.00003557534,0.00005233422,0.0008472737,0.00002461381,0.001673045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004871891,"threshold_uncertainty_score":0.01629817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021326750483873,"score_gpt":0.2631739332519861,"score_spread":0.2418471827681131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}