{"id":"W4399482309","doi":"10.1136/annrheumdis-2024-eular.3541","title":"POS0155 PRE-DIAGNOSTIC IMMUNOMODULATORY AMINO ACID METABOLITES AND RISK OF GOUT, ACCOUNTING FOR SERUM URATE: A PROSPECTIVE STUDY OF 249,677 INDIVIDUALS AND MENDELIAN RANDOMIZATION ANALYSES","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Canada","funders":"","keywords":"Mendelian randomization; Gout; Medicine; Uric acid; Internal medicine; Chemistry; Biochemistry; Gene; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001999679,0.001284058,0.0009415648,0.0007510058,0.0009513724,0.0009888908,0.0008447326,0.001312992,0.003123212],"category_scores_gemma":[0.002908579,0.001247736,0.001814901,0.001222303,0.0006660784,0.0006426417,0.0005727256,0.0009624605,0.0004362791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002437187,"about_ca_system_score_gemma":0.0004020866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003059403,"about_ca_topic_score_gemma":0.002036776,"domain_scores_codex":[0.9978245,0.0009340528,0.000162163,0.0007010485,0.000133562,0.0002446978],"domain_scores_gemma":[0.9979175,0.0006910315,0.0004210032,0.0006072885,0.00009203824,0.0002711831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02600981,0.0005965352,0.9634122,0.00003897387,0.001900031,0.0005808674,0.0001446222,0.0004442608,0.003966678,0.0002277928,0.0002138679,0.002464453],"study_design_scores_gemma":[0.001185071,0.004135394,0.9871833,0.00001281734,0.001615931,0.0009584103,0.0002710722,0.003025431,0.0007679042,0.000335589,0.0004610645,0.00004798591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989911,0.0001574173,0.0004028806,0.00001305272,0.00001665045,0.00001045091,0.0002328579,0.00000917843,0.0001664439],"genre_scores_gemma":[0.9990559,0.00003930339,0.0002308037,0.00001739207,0.00001292775,0.00001494511,0.0002490966,0.000007729,0.0003719772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003123212,"threshold_uncertainty_score":0.01057541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762231872130951,"score_gpt":0.312261084551066,"score_spread":0.2946387658297566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}