{"id":"W4399483244","doi":"10.1136/annrheumdis-2024-eular.602","title":"OP0046 EFFECT OF IXEKIZUMAB TREATMENT ON MRI STRUCTURAL LESIONS IN THE SACROILIAC JOINTS OF PATIENTS WITH RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS; A POST-HOC ANALYSIS OF A PLACEBO AND ACTIVE CONTROLLED RCT","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Ixekizumab; Medicine; Axial spondyloarthritis; Post-hoc analysis; Placebo; Randomized controlled trial; Radiography; Sacroiliac joint; Physical therapy; Magnetic resonance imaging; Radiology; Internal medicine; Sacroiliitis; Arthritis; Pathology; Secukinumab; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003816029,0.002470842,0.007647705,0.0005818609,0.0005337671,0.002046324,0.001272037,0.002663843,0.00846857],"category_scores_gemma":[0.005420456,0.001090995,0.007059128,0.0005610093,0.001466606,0.00164116,0.0007448892,0.003979264,0.0009430436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008226313,"about_ca_system_score_gemma":0.001255267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00163285,"about_ca_topic_score_gemma":0.002285897,"domain_scores_codex":[0.9973674,0.001604233,0.0002024553,0.0003571793,0.0001507153,0.0003179751],"domain_scores_gemma":[0.9967219,0.001938856,0.0004923008,0.0002517029,0.0002653249,0.0003299205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9901337,0.0008963941,0.0002840864,0.0008050933,0.003715456,0.00002802156,0.00002656456,0.0001306371,0.0007941313,0.00003870624,0.0001544006,0.002992764],"study_design_scores_gemma":[0.8917653,0.09058387,0.004966977,0.0001190043,0.01060158,0.00002863166,0.00008987387,0.0004194599,0.0006193868,0.0001345245,0.0006324195,0.0000390492],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822583,0.008769834,0.0009168659,0.0005078054,0.001460445,0.002208113,0.001429249,0.000116562,0.002332831],"genre_scores_gemma":[0.9906984,0.001892478,0.001008039,0.0003999764,0.0006434775,0.001262985,0.0007501776,0.00002725756,0.003317185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00846857,"threshold_uncertainty_score":0.02833021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198183152188291,"score_gpt":0.2960203829028881,"score_spread":0.2840385513810052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}