{"id":"W4399483383","doi":"10.1136/annrheumdis-2024-eular.618","title":"POS0899 FIRST-IN-HUMAN SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS DATA WITH MK-6194, A MODIFIED FORM OF INTERLEUKIN-2, DESIGNED TO SELECTIVELY ACTIVATE REGULATORY T-CELLS – SINGLE ASCENDING DOSE AND MULTIPLE ASCENDING DOSE TRIALS","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"Pharmacokinetics; Pharmacodynamics; Pharmacology; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002303846,0.001191287,0.00132421,0.000415048,0.0003809751,0.001287243,0.0005732127,0.001474032,0.0032551],"category_scores_gemma":[0.001982627,0.0004509703,0.001779329,0.0004175301,0.001065568,0.001261998,0.0002503414,0.004020473,0.001522392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007219411,"about_ca_system_score_gemma":0.0007755074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002758316,"about_ca_topic_score_gemma":0.0003531979,"domain_scores_codex":[0.9991485,0.0004492085,0.00006924925,0.0001174669,0.0001137792,0.0001018202],"domain_scores_gemma":[0.9984245,0.0004473448,0.0003769017,0.0002729627,0.0001339834,0.0003442249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6068241,0.02898386,0.007292513,0.0009445178,0.002701682,0.0007512097,0.0004742332,0.005470064,0.1320707,0.001498558,0.009001575,0.203987],"study_design_scores_gemma":[0.1328733,0.7689595,0.01866792,0.0001653789,0.001666341,0.002476228,0.0001735104,0.003408194,0.05087924,0.001626991,0.01898276,0.0001206084],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831564,0.004882149,0.002854597,0.0007365582,0.000266907,0.0006223322,0.002721607,0.0002750451,0.004484526],"genre_scores_gemma":[0.989449,0.002503164,0.001163194,0.0008324053,0.0001622101,0.0003592554,0.002928001,0.00006872155,0.00253407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0032551,"threshold_uncertainty_score":0.01218402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09399967121303109,"score_gpt":0.3695136254530998,"score_spread":0.2755139542400687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}