{"id":"W4399483383","doi":"10.1136/annrheumdis-2024-eular.618","title":"POS0899 FIRST-IN-HUMAN SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS DATA WITH MK-6194, A MODIFIED FORM OF INTERLEUKIN-2, DESIGNED TO SELECTIVELY ACTIVATE REGULATORY T-CELLS – SINGLE ASCENDING DOSE AND MULTIPLE ASCENDING DOSE TRIALS","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"Pharmacokinetics; Pharmacodynamics; Pharmacology; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001476495,0.0002927394,0.000816963,0.0002459633,0.0001447304,0.00005397988,0.0004678572,0.000111187,0.00004423993],"category_scores_gemma":[0.0006330474,0.0001892805,0.0001266919,0.0003369575,0.0003781159,0.0002158801,0.000480867,0.0001942398,9.635885e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003628831,"about_ca_system_score_gemma":0.0000629374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006696273,"about_ca_topic_score_gemma":0.00002984417,"domain_scores_codex":[0.9976864,0.0005676731,0.0007824778,0.0004829511,0.0001088589,0.0003715923],"domain_scores_gemma":[0.9972804,0.001799027,0.0003134772,0.0004423189,0.00007270344,0.00009209722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004312288,0.0009743897,0.001019323,0.001998469,0.002375819,0.00001006455,0.001413053,0.0001920512,0.9001299,0.0006541327,0.001881854,0.08503862],"study_design_scores_gemma":[0.008005247,0.001278344,0.02161893,0.007695958,0.002007951,0.00003853326,0.0007134181,0.01897273,0.9351915,0.002479463,0.001052441,0.0009455312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902913,0.005459343,0.0009658498,0.001021374,0.0002916851,0.0009875196,0.0008592603,0.00004186821,0.00008180178],"genre_scores_gemma":[0.9981781,0.0009144811,0.0005606839,0.0001587611,0.00001538195,0.00001060764,0.00003099238,0.00003043795,0.0001006115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08409309,"threshold_uncertainty_score":0.7718636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09399967121303109,"score_gpt":0.3695136254530998,"score_spread":0.2755139542400687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}