{"id":"W4399483733","doi":"10.1136/annrheumdis-2024-eular.4464","title":"POS0556 DNA METHYLATION ESTIMATES OF HYPER-AGING IN SYSTEMIC SCLEROSIS AND IDIOPATHIC PULMONARY FIBROSIS","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Coastal Health Research Institute; Vancouver Coastal Health; Providence Health Care; Institute of Infection and Immunity; BC Children's Hospital; University of Calgary; University of Northern British Columbia; University of British Columbia","funders":"","keywords":"DNA methylation; Pulmonary fibrosis; Medicine; Multiple sclerosis; Fibrosis; DNA; Methylation; Idiopathic pulmonary fibrosis; Pathology; Immunology; Internal medicine; Biology; Lung; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004606107,0.00024705,0.0003482092,0.0008001488,0.0003727688,0.0006955793,0.0002196855,0.0004742287,0.003860109],"category_scores_gemma":[0.001229166,0.0001923755,0.0003900193,0.0006562024,0.0002489979,0.0002215127,0.0003290191,0.0003375634,0.0007243403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001635425,"about_ca_system_score_gemma":0.0001290385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200515,"about_ca_topic_score_gemma":0.001754185,"domain_scores_codex":[0.9995678,0.00009648622,0.00006018522,0.0001392475,0.00008023276,0.00005604019],"domain_scores_gemma":[0.9993274,0.00019988,0.0002184931,0.00006436801,0.00009619496,0.0000937879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002577824,0.00006570818,0.9098214,0.00008790664,0.0005046126,0.0002512792,0.000249068,0.0003077171,0.06939545,0.0002065683,0.0004077843,0.01612473],"study_design_scores_gemma":[0.00001916477,0.0002828244,0.987558,0.00001451943,0.0002027768,0.0009187125,0.0001780342,0.0006500949,0.008335731,0.0002317904,0.001597297,0.00001115416],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962196,0.0009125347,0.000496032,0.00004307125,0.00002361296,0.000003911934,0.0008787418,0.00001808988,0.001404481],"genre_scores_gemma":[0.9984481,0.00009538802,0.0002355567,0.00004012317,0.00001231611,0.000006698855,0.0004478097,0.000007120206,0.0007068715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003860109,"threshold_uncertainty_score":0.01291335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04298557032542116,"score_gpt":0.2919383067518168,"score_spread":0.2489527364263956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}