{"id":"W4399483910","doi":"10.1136/annrheumdis-2024-eular.5050","title":"POS0862 THE EFFICACY OF EOSINOPHIL-TARGETING THERAPIES ACCORDING TO ANCA STATUS IN PATIENTS WITH EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS: A POST-HOC ANALYSIS OF THE PHASE 3 MANDARA STUDY","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Eosinophilic Esophagitis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"","keywords":"Granulomatosis with polyangiitis; Eosinophilic; Medicine; Post-hoc analysis; Eosinophil; Post hoc; Internal medicine; Pathology; Vasculitis; Disease; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004583005,0.002040277,0.006560392,0.0003706399,0.0006137152,0.001584248,0.001054295,0.001415336,0.003588576],"category_scores_gemma":[0.002958741,0.0007616788,0.005814389,0.0004786932,0.001327969,0.002025712,0.0007503894,0.004188471,0.0007869577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006245524,"about_ca_system_score_gemma":0.001181533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004457138,"about_ca_topic_score_gemma":0.001513649,"domain_scores_codex":[0.9964274,0.00251005,0.0001345641,0.0003568925,0.0001297424,0.0004413879],"domain_scores_gemma":[0.9972485,0.001493594,0.0003349916,0.0003818402,0.0001384608,0.0004025715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9801293,0.002082825,0.002354685,0.0001615866,0.003339965,0.00003755548,0.0000447226,0.0007712952,0.002431422,0.00007182042,0.0004589584,0.008115817],"study_design_scores_gemma":[0.5288779,0.4147699,0.04035868,0.00006468066,0.007810066,0.0001233101,0.0001880985,0.002992038,0.002349536,0.0005411629,0.001789389,0.0001352796],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995801,0.00165778,0.0003199111,0.00024772,0.0002037085,0.0002732503,0.0005975176,0.00004688897,0.0008521574],"genre_scores_gemma":[0.9957481,0.000490243,0.0006187533,0.0003538258,0.0002230443,0.0005004102,0.0008665827,0.00003681805,0.001162262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006560392,"threshold_uncertainty_score":0.02423751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410071631904819,"score_gpt":0.3033160456723066,"score_spread":0.2892153293532584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}