{"id":"W4399484116","doi":"10.1136/annrheumdis-2024-eular.3024","title":"OP0008 SAFETY AND EFFICACY OF ISCALIMAB IN PATIENTS WITH SJÖGREN’S DISEASE: 48-WEEK RESULTS FROM A RANDOMISED, PLACEBO-CONTROLLED, PHASE 2B DOSE-RANGING TRIAL","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Dose-ranging study; Placebo; Medicine; Randomized controlled trial; Internal medicine; Double blind; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002367054,0.002100752,0.004248904,0.0005996944,0.0004833593,0.001607126,0.001103196,0.003194742,0.006856653],"category_scores_gemma":[0.002383626,0.0007500934,0.002577387,0.0005341308,0.001761108,0.001592494,0.0004745488,0.004513065,0.001412707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006068219,"about_ca_system_score_gemma":0.0007861134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005474132,"about_ca_topic_score_gemma":0.0007596195,"domain_scores_codex":[0.9991615,0.0004019261,0.00004970408,0.0001479489,0.00008051811,0.0001584281],"domain_scores_gemma":[0.9987091,0.000472325,0.0002613434,0.000116691,0.00008831731,0.0003522204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9626589,0.005147677,0.0006399992,0.001024637,0.001126717,0.00007320337,0.00007154316,0.0004120878,0.003926998,0.000100378,0.0009915383,0.02382622],"study_design_scores_gemma":[0.9303678,0.06489175,0.002805143,0.00004656718,0.0004412943,0.00006309715,0.00002779105,0.0003078679,0.0003741436,0.0001381305,0.0005134398,0.00002308389],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872903,0.006641618,0.0005025367,0.0007425976,0.0004580189,0.001177861,0.0008462573,0.0001859201,0.002154907],"genre_scores_gemma":[0.9871449,0.002979948,0.001039936,0.001367391,0.000690873,0.001581602,0.001529951,0.00004388841,0.003621469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006856653,"threshold_uncertainty_score":0.02293777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187191324469023,"score_gpt":0.288026349035616,"score_spread":0.2661544357909257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}