{"id":"W4399493969","doi":"10.3390/cancers16122175","title":"G9a in Cancer: Mechanisms, Therapeutic Advancements, and Clinical Implications","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Terry Fox Research Institute","keywords":"Epigenetics; PRC2; Prostate cancer; EZH2; Biology; Cancer; Histone methyltransferase; Methyltransferase; Cancer research; Bioinformatics; Genetics; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006595078,0.0005134817,0.0007325773,0.0009203412,0.0002973149,0.0009160832,0.0004459654,0.00104556,0.002950066],"category_scores_gemma":[0.0006226742,0.0001444911,0.0005121915,0.0008411595,0.0006353959,0.0009673379,0.0006706128,0.00169362,0.0008958483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007459152,"about_ca_system_score_gemma":0.001047659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007292941,"about_ca_topic_score_gemma":0.00203133,"domain_scores_codex":[0.999862,0.00003431147,0.00001362684,0.0000292578,0.00003378348,0.00002716679],"domain_scores_gemma":[0.999808,0.00007283551,0.00002434524,0.00001092673,0.00004502277,0.00003891702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007295507,0.0002582608,0.00301948,0.007175209,0.0001916174,0.0009465786,0.0001408622,0.001290563,0.01576413,0.0166749,0.02752744,0.9262814],"study_design_scores_gemma":[0.000213776,0.001222152,0.00868746,0.00352334,0.0005191853,0.006211254,0.0003308876,0.001447784,0.01036988,0.02080188,0.946593,0.00007948899],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00234679,0.9908243,0.0006486124,0.003677462,0.0003439648,0.00001157524,0.00006274405,0.00002989729,0.002054581],"genre_scores_gemma":[0.02224558,0.9736962,0.001089736,0.001079334,0.0006653211,0.00002099479,0.0001386538,0.000008198619,0.001055968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002950066,"threshold_uncertainty_score":0.009868979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03363133398590185,"score_gpt":0.3818259868793862,"score_spread":0.3481946528934844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}