{"id":"W4399495182","doi":"10.3390/cells13121010","title":"Efficient Generation of Pancreatic Progenitor Cells from Induced Pluripotent Stem Cells Derived from a Non-Invasive and Accessible Tissue Source—The Plucked Hair Follicle","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Mitacs","keywords":"Induced pluripotent stem cell; Reprogramming; Regenerative medicine; Progenitor cell; Stem cell; Hair follicle; Biology; Cell biology; PDX1; Stromal cell; Cancer research; Immunology; Embryonic stem cell; Cell; Endocrinology; Insulin; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000217584,0.0003244891,0.000348791,0.0000875274,0.0001533194,0.0001832589,0.0004163566,0.0002638519,0.0000535389],"category_scores_gemma":[0.00001410665,0.0002548296,0.0001389099,0.0002168511,0.0001471989,0.000009336555,0.0003627241,0.0002025821,0.000102992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005268891,"about_ca_system_score_gemma":0.0002366962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006074982,"about_ca_topic_score_gemma":0.00008979492,"domain_scores_codex":[0.997663,0.0002095893,0.0004584744,0.0008158383,0.0004220642,0.000431036],"domain_scores_gemma":[0.9987516,0.0001451783,0.0001466355,0.0006399452,0.0001276269,0.0001889573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007083547,0.00009360461,0.00008782108,0.0001200984,0.0002217873,0.00002142967,0.0006454863,0.001595202,0.9933652,6.622702e-7,0.0008472388,0.002930605],"study_design_scores_gemma":[0.0006676368,0.0002144671,0.0001240175,0.0001046831,0.0001201988,0.000002132409,0.000357196,0.02314789,0.97317,0.000007247068,0.001813378,0.0002711416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908737,0.003759983,0.003250863,0.00009808551,0.0005988091,0.001115007,0.0002156031,0.00003023497,0.00005769534],"genre_scores_gemma":[0.9969591,0.0003810106,0.0006814969,0.00006064761,0.0005340199,0.0001075812,0.0001339418,0.00006591866,0.001076268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02155269,"threshold_uncertainty_score":0.9999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179262910363435,"score_gpt":0.2570710976250599,"score_spread":0.2352784685214256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}