{"id":"W4399500567","doi":"10.1098/rstb.2023.0222","title":"GluN2A- and GluN2B-containing pre-synaptic N -methyl- d -aspartate receptors differentially regulate action potential-evoked Ca 2+ influx via modulation of SK channels","year":2024,"lang":"en","type":"article","venue":"Philosophical Transactions of the Royal Society B Biological Sciences","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Medical Research Council; Clarendon Fund; University of Oxford","keywords":"NMDA receptor; Neuroscience; Synaptic plasticity; Schaffer collateral; Neurotransmission; Receptor; Electrophysiology; Biology; Protein subunit; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152744,0.0002526346,0.0002657206,0.00008009282,0.0001198113,0.0003605029,0.0002447018,0.0003368055,0.001356513],"category_scores_gemma":[0.0001466055,0.0001094767,0.0002242042,0.0000943841,0.0002814592,0.000414006,0.0001834337,0.0003938413,0.0003027955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002813433,"about_ca_system_score_gemma":0.0001548271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004616065,"about_ca_topic_score_gemma":0.001343269,"domain_scores_codex":[0.999892,0.00001243569,0.00001127955,0.00002631257,0.00002763317,0.00003032503],"domain_scores_gemma":[0.9999372,0.000007708899,0.00001707528,0.000006638968,0.000009875538,0.00002158518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001376885,0.000007606922,0.000171219,0.00002363502,0.000004969136,0.00002670025,0.000006640244,0.00001805019,0.9985196,0.00006701658,0.00003076761,0.0009860689],"study_design_scores_gemma":[0.00004034819,0.0003013305,0.02555676,0.00001225755,0.00003684109,0.0005438105,0.00006999817,0.001042996,0.9694606,0.0002274473,0.002699447,0.000008092713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909368,0.00292316,0.002742294,0.0001645393,0.00006725249,0.00001648879,0.0001634928,0.00004442398,0.002941644],"genre_scores_gemma":[0.9930316,0.001957988,0.002273365,0.0001550304,0.00002103368,0.00003377417,0.0002163415,0.00002430837,0.002286524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356513,"threshold_uncertainty_score":0.004538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0637834713815051,"score_gpt":0.3136883372365691,"score_spread":0.2499048658550641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}