{"id":"W4399504392","doi":"10.1158/1538-8514.synthleth24-a020","title":"Abstract A020: TP53 mutation and prediction of platinum response in BRCA-mutated ovarian cancer: A prospective case-series analysis","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Ovarian cancer; BRCA mutation; Medicine; Olaparib; Oncology; Missense mutation; Internal medicine; Germline mutation; Nonsense mutation; PARP inhibitor; Cancer; Germline; Serous fluid; Mutation; Somatic cell; Cancer research; Genetics; Biology; Gene; Poly ADP ribose polymerase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003845537,0.0004144883,0.000471782,0.001864417,0.0006780839,0.0006325551,0.0004661644,0.0007467211,0.003161767],"category_scores_gemma":[0.001777044,0.0005638306,0.0004790047,0.001132335,0.0006321718,0.000430796,0.0005396627,0.00048341,0.0004917699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004227915,"about_ca_system_score_gemma":0.0003730836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001872714,"about_ca_topic_score_gemma":0.001599445,"domain_scores_codex":[0.999508,0.00007629815,0.0000642919,0.0002004434,0.00006793292,0.00008295351],"domain_scores_gemma":[0.9987212,0.0003581937,0.0003777028,0.0001857985,0.00008615451,0.0002709991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001206475,0.0000547683,0.9818242,0.00001638867,0.00003100272,0.0164818,0.00007717641,0.00003884165,0.0003744923,0.00002272922,0.000102735,0.0008552384],"study_design_scores_gemma":[0.00003560721,0.0003013494,0.902207,0.00002011035,0.00008795985,0.09559389,0.000389201,0.000481954,0.0003387239,0.00007111145,0.0004542363,0.00001886842],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992934,0.000176874,0.0000753986,0.00001738468,0.000003792591,0.00001421919,0.0001262543,0.000003298449,0.0002892541],"genre_scores_gemma":[0.999631,0.00006476094,0.00005364812,0.00001208018,0.00001297742,0.00000703415,0.000146162,0.000001856447,0.00007039938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003161767,"threshold_uncertainty_score":0.01057714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017370463947797,"score_gpt":0.3064825006325342,"score_spread":0.2863087959930562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}