{"id":"W4399504483","doi":"10.1158/1538-8514.synthleth24-b017","title":"Abstract B017: Loss of UXS1 selectively kills KEAP1 mutant cancer cell lines by depleting pyrimidines and inducing replication stress","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Mutant; Cancer cell; Molecular biology; Cancer research; Cancer; Biochemistry; Chemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054149,0.0005063093,0.0004599877,0.0003449902,0.0003149612,0.0003295477,0.0003335957,0.0004202166,0.007018263],"category_scores_gemma":[0.0001032921,0.0001556197,0.000315671,0.0003234849,0.0002125924,0.0001817242,0.0002697025,0.0007024455,0.001652939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002772554,"about_ca_system_score_gemma":0.000264232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00109781,"about_ca_topic_score_gemma":0.0009477252,"domain_scores_codex":[0.999796,0.00001710031,0.00002124913,0.00004221178,0.00007709116,0.00004636385],"domain_scores_gemma":[0.9998924,0.00001686916,0.0000210851,0.00001597574,0.00001507208,0.00003867687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002615379,0.0000601415,0.0002165663,0.00004980896,0.000007125479,0.00004597447,0.00001000654,0.00005266472,0.9969289,0.00008106843,0.0003903783,0.001895829],"study_design_scores_gemma":[0.00001791083,0.0003771329,0.00259172,0.00000538342,0.00001114926,0.0001772875,0.00002234922,0.0005267997,0.9924681,0.00003112129,0.003766707,0.00000446566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980136,0.002931934,0.003821765,0.0003651659,0.0001783008,0.00009476638,0.007190834,0.0008536249,0.004427471],"genre_scores_gemma":[0.9688886,0.0011793,0.004592044,0.0001555585,0.00001836814,0.000166535,0.01132304,0.00012949,0.013547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007018263,"threshold_uncertainty_score":0.02347845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778759834117769,"score_gpt":0.2980180303979056,"score_spread":0.2802304320567279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}