{"id":"W4399504496","doi":"10.1158/1538-8514.synthleth24-a009","title":"Abstract A009: Synthetic lethality in the context of STAG2-mutant Ewing sarcoma","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Synthetic lethality; Sarcoma; Context (archaeology); Cancer research; Biology; Metastasis; Cancer; CRISPR; Mutant; Genetics; Medicine; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134827,0.0005298523,0.000315197,0.000439524,0.0002858843,0.0003643276,0.0004539661,0.0005590087,0.003662786],"category_scores_gemma":[0.000164658,0.0001587674,0.0003326442,0.000255004,0.0003781792,0.000165152,0.0004892512,0.001007695,0.001487803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004241069,"about_ca_system_score_gemma":0.0002622148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009151284,"about_ca_topic_score_gemma":0.001124062,"domain_scores_codex":[0.9996758,0.00004683634,0.00004221725,0.00006719035,0.0001257212,0.00004235961],"domain_scores_gemma":[0.9998021,0.00004973822,0.00005161004,0.00002724603,0.00001303683,0.00005634268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005088635,0.00003396088,0.000135644,0.00003081936,0.000006682524,0.000169782,0.00001313508,0.0001264286,0.9981259,0.0002489722,0.000153113,0.0009047718],"study_design_scores_gemma":[0.00002070512,0.000301257,0.002376321,0.00001171698,0.000018719,0.001170607,0.00003150428,0.001956164,0.9862235,0.00009792159,0.00777987,0.0000117904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677806,0.0009768393,0.01841049,0.0002960933,0.0001689117,0.0002565157,0.005849457,0.000764062,0.005497085],"genre_scores_gemma":[0.974888,0.0006386057,0.009865417,0.0001528757,0.00001678422,0.0002014276,0.004756519,0.0002308868,0.009249561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003662786,"threshold_uncertainty_score":0.01225328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265139586324882,"score_gpt":0.2937527950404102,"score_spread":0.2711013991771614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}