{"id":"W4399504538","doi":"10.1158/1538-8514.synthleth24-pr001","title":"Abstract PR001: KIF18A inhibition, via ATX020, leads to mitotic arrest and robust anti-tumor activity through a synthetic lethal interaction with chromosome instability","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Mitosis; Cell cycle checkpoint; Kinesin; Mitotic catastrophe; Cell cycle; Cell biology; Synthetic lethality; Biology; Genome instability; Cell growth; Chromosome instability; DNA damage; Microtubule; Molecular biology; Apoptosis; DNA repair; Genetics; Chromosome; DNA; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008505231,0.0005052981,0.0002856347,0.0002722911,0.0001373616,0.0002633942,0.0003370045,0.0003497712,0.00592197],"category_scores_gemma":[0.00005994918,0.0001312008,0.0002222964,0.0002536792,0.0001901939,0.0001490151,0.0001460892,0.0008096108,0.001389472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002708105,"about_ca_system_score_gemma":0.0003164647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008412208,"about_ca_topic_score_gemma":0.0009971315,"domain_scores_codex":[0.9999017,0.000008805079,0.00001046675,0.00002097483,0.00003310568,0.00002490271],"domain_scores_gemma":[0.9999475,0.000007203583,0.00001386315,0.000004692314,0.000005417224,0.00002136956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004014178,0.000172359,0.00009488586,0.00006794042,0.000009253551,0.00007599017,0.00001195846,0.0001038991,0.9952968,0.0001767254,0.0005378562,0.003050892],"study_design_scores_gemma":[0.00007201169,0.001232698,0.001745689,0.000006398664,0.00001257189,0.0002289374,0.00001397923,0.0005141879,0.991532,0.00002849252,0.004608462,0.000004628336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804555,0.002744251,0.002669663,0.0002958085,0.0001338523,0.0001458288,0.003678202,0.0007119451,0.009164968],"genre_scores_gemma":[0.9710779,0.001614774,0.002228389,0.0001067086,0.00002052221,0.0001716129,0.005539998,0.00006295873,0.01917716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00592197,"threshold_uncertainty_score":0.01981091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625203597929133,"score_gpt":0.2701834701455655,"score_spread":0.2539314341662742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}