{"id":"W4399504621","doi":"10.1158/1538-8514.synthleth24-b020","title":"Abstract B020: Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Helicase; Cancer; Microsatellite instability; Cancer cell; DNA; DNA replication; Biology; DNA damage; In vivo; Molecular biology; Cancer research; Genetics; Microsatellite; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208705,0.0005316343,0.0003184452,0.000373623,0.0002164988,0.0005006891,0.0004066839,0.0004614198,0.00543131],"category_scores_gemma":[0.00006963271,0.000159136,0.0001972849,0.0001877886,0.0001422399,0.0002107458,0.0001966709,0.0004992316,0.001969054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003213538,"about_ca_system_score_gemma":0.0003575456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027515,"about_ca_topic_score_gemma":0.002319899,"domain_scores_codex":[0.9999371,0.000006274615,0.000004655683,0.00001527648,0.00002382649,0.0000128721],"domain_scores_gemma":[0.9999595,0.000003592464,0.000007042959,0.000003278715,0.000009417782,0.0000172174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003373785,0.0001411323,0.0001467915,0.0001346849,0.00001385789,0.0001429878,0.00001357154,0.0002133631,0.9737188,0.0004900261,0.00412862,0.02051873],"study_design_scores_gemma":[0.0002392317,0.001671101,0.002569792,0.00001974569,0.00002968054,0.0007797162,0.00001641809,0.001152132,0.9496018,0.0001521003,0.04374918,0.00001917855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8371769,0.0497695,0.02078198,0.002496127,0.001595363,0.0008895529,0.00611633,0.003285257,0.07788907],"genre_scores_gemma":[0.8567945,0.01983368,0.01380059,0.001092122,0.0001780496,0.0003610403,0.005775345,0.0001988712,0.1019659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00543131,"threshold_uncertainty_score":0.01816958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01924233646334732,"score_gpt":0.2879796761595906,"score_spread":0.2687373396962433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}