{"id":"W4399504653","doi":"10.1158/1538-8514.synthleth24-a019","title":"Abstract A019: Inhibition of nicotinamide adenine dinucleotide (NAD) production is a potent therapeutic strategy to inactivate homologous recombination in cancer cells","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"","keywords":"RAD51; Synthetic lethality; Olaparib; DNA repair; Homologous recombination; Genome instability; Biology; Poly ADP ribose polymerase; PALB2; NAD+ kinase; Cancer cell; DNA damage; Cancer research; PARP inhibitor; Nicotinamide phosphoribosyltransferase; Cancer; Cell biology; DNA; Mutation; Genetics; Biochemistry; Germline mutation; Enzyme; Polymerase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006313051,0.0004683209,0.0002303665,0.0002820895,0.0001353049,0.0002191261,0.0002438373,0.000235891,0.003356728],"category_scores_gemma":[0.00003895113,0.0000778711,0.0001693431,0.0002063784,0.0000942864,0.0001052583,0.0001302904,0.0005853162,0.00101701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002708898,"about_ca_system_score_gemma":0.0001452235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005928577,"about_ca_topic_score_gemma":0.0006989611,"domain_scores_codex":[0.9999412,0.000007734447,0.000004781643,0.00001392552,0.00002059628,0.00001175568],"domain_scores_gemma":[0.9999765,0.000002799273,0.000007514828,0.000002273569,0.000003599786,0.000007292615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001794448,0.0001344132,0.0001538499,0.0001386105,0.00001263676,0.00006536799,0.000006985424,0.0001116829,0.9857555,0.0002670035,0.0006046994,0.01256969],"study_design_scores_gemma":[0.00003743582,0.0007057934,0.001383557,0.00001021076,0.00002091164,0.0002585874,0.000006453305,0.0003575951,0.9783632,0.00004707489,0.01880547,0.000003769909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094059,0.02868681,0.02515549,0.000878958,0.0006678185,0.0003936923,0.004345377,0.00116842,0.02929758],"genre_scores_gemma":[0.959079,0.007469427,0.007451857,0.0002074099,0.00003958336,0.0001642128,0.00225223,0.00004252449,0.02329382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003356728,"threshold_uncertainty_score":0.01122934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03737261863275776,"score_gpt":0.3369266505763999,"score_spread":0.2995540319436422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}