{"id":"W4399504765","doi":"10.1158/1538-8514.synthleth24-ia010","title":"Abstract IA010: Targeting genome instability in cancer: Translating synthetic lethal biology into the clinic","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer; Cancer research; Genome instability; Ovarian cancer; Medicine; Cyclin-dependent kinase 1; Biology; Cell cycle; Synthetic lethality; Chromosome instability; Mitosis; Genome; Genetics; Gene; DNA damage; DNA; DNA repair","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009369284,0.0006944984,0.000413649,0.0008827548,0.0003735575,0.001884085,0.0007482094,0.001096526,0.02412672],"category_scores_gemma":[0.0004868101,0.0002197568,0.0002924752,0.0005019531,0.0005967299,0.000724756,0.0007234294,0.002269265,0.006390824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002324688,"about_ca_system_score_gemma":0.001828834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004471911,"about_ca_topic_score_gemma":0.009526088,"domain_scores_codex":[0.9997676,0.00004259474,0.00001117416,0.0000308925,0.00008375872,0.00006397565],"domain_scores_gemma":[0.9997163,0.00002626145,0.00002884013,0.00001531782,0.00008508611,0.0001281407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001152983,0.0005832306,0.0006547315,0.0007890539,0.00003770342,0.0003355214,0.0001059354,0.00086267,0.06635604,0.01894842,0.5041678,0.4060058],"study_design_scores_gemma":[0.000526057,0.00151197,0.001866956,0.0003084485,0.00006553553,0.0006813997,0.00005988644,0.001077482,0.03190414,0.002836304,0.9591244,0.00003733988],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.05418476,0.3380595,0.02786464,0.1118437,0.03177186,0.001544848,0.00841833,0.005489605,0.4208228],"genre_scores_gemma":[0.2610525,0.26486,0.0215489,0.03056339,0.009338599,0.0006923551,0.007315873,0.000574915,0.4040535],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02412672,"threshold_uncertainty_score":0.0807119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397910053171153,"score_gpt":0.319700081945374,"score_spread":0.2957209814136624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}