{"id":"W4399505041","doi":"10.1158/1538-8514.synthleth24-a016","title":"Abstract A016: Companion Diagnostics (CDx) to identify hallmarks of Alternative Lengthening of Telomeres (ALT)","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Telomere; Telomerase; Cancer; Cancer research; Biomarker; Biology; Computational biology; Molecular biology; Medicine; DNA; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001983143,0.001082163,0.0007648639,0.002048007,0.0007280629,0.001635715,0.0007018406,0.001632546,0.02751663],"category_scores_gemma":[0.002627223,0.0004240474,0.0004439904,0.0009980277,0.0005918668,0.0008896493,0.001062275,0.001720655,0.01231169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006441228,"about_ca_system_score_gemma":0.0007938289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004331062,"about_ca_topic_score_gemma":0.0005814044,"domain_scores_codex":[0.9986115,0.0002581298,0.00009942846,0.0003927481,0.0005559861,0.00008228857],"domain_scores_gemma":[0.9978899,0.0004803193,0.0004156792,0.0001989172,0.0007121052,0.0003030756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001414438,0.0002661319,0.007470797,0.001302419,0.00006393665,0.000667111,0.0002565676,0.0005432257,0.7534837,0.004704393,0.05861807,0.1712092],"study_design_scores_gemma":[0.0001481475,0.001791171,0.01152502,0.0002512517,0.0001018109,0.0036726,0.0001762887,0.003378679,0.6929523,0.002145542,0.2837347,0.0001225406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3575503,0.03911901,0.3626809,0.0130101,0.01718855,0.004665772,0.04660225,0.02980075,0.1293824],"genre_scores_gemma":[0.469646,0.01411004,0.3079996,0.005119083,0.002118427,0.00297401,0.02893678,0.001578155,0.1675179],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02751663,"threshold_uncertainty_score":0.09205228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02344545825352707,"score_gpt":0.3276595688487436,"score_spread":0.3042141105952165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}