{"id":"W4399505067","doi":"10.1158/1538-8514.synthleth24-a017","title":"Abstract A017: Characterizing intratumoral heterogeneity of <i>CCNE1</i> amplification in ovarian cancer using digital pathology","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"Ovarian cancer; Biology; Cancer research; Synthetic lethality; Cancer; Gene; Genetics; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007592711,0.000320444,0.0002001253,0.002374523,0.0002516871,0.0009865124,0.0002728447,0.000425842,0.002567376],"category_scores_gemma":[0.001317702,0.0001841257,0.0001953924,0.000741081,0.0003077801,0.00039568,0.0004437693,0.0002996663,0.000663518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004640418,"about_ca_system_score_gemma":0.0002890793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001514493,"about_ca_topic_score_gemma":0.002384241,"domain_scores_codex":[0.9997231,0.00003478821,0.00002431524,0.00007964825,0.0001078791,0.0000302675],"domain_scores_gemma":[0.9994168,0.0001411284,0.0001609673,0.00005899781,0.000157611,0.00006450134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001512079,0.0001459832,0.3874728,0.0005207913,0.0002163031,0.0008140585,0.0002457005,0.007996266,0.4091531,0.001318672,0.006455958,0.1841483],"study_design_scores_gemma":[0.00005972228,0.0004262747,0.6162279,0.0001012258,0.0002312708,0.005650773,0.0004789295,0.1019515,0.2531526,0.00188001,0.01975909,0.00008070236],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595047,0.001359448,0.02751343,0.0002452502,0.00004271547,0.0002121474,0.003506359,0.001322397,0.006293689],"genre_scores_gemma":[0.9640657,0.0005352026,0.02974786,0.0001034112,0.00002885516,0.0001541504,0.003093387,0.0001025311,0.002168902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002567376,"threshold_uncertainty_score":0.008588731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823615659350954,"score_gpt":0.302029070117898,"score_spread":0.2737929135243884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}