{"id":"W4399505148","doi":"10.1158/1538-8514.synthleth24-ia022","title":"Abstract IA022: Mechanisms of splicing dysregulation and dependency in cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"RNA splicing; Biology; Alternative splicing; Splicing factor; RNA-binding protein; Exonic splicing enhancer; Genetics; RNA; Gene; Computational biology; Messenger RNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585962,0.000120411,0.000120517,0.00008746328,0.00002553502,0.00002952451,0.00009826465,0.0001093709,0.00002611432],"category_scores_gemma":[0.000005081829,0.0001144183,0.00005021477,0.000144268,0.00003964099,0.000006248257,0.00004877491,0.000118085,7.855255e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003647111,"about_ca_system_score_gemma":0.0001254237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005424714,"about_ca_topic_score_gemma":0.0004659294,"domain_scores_codex":[0.9991293,0.00002759627,0.0001789058,0.0002726459,0.0001736838,0.000217856],"domain_scores_gemma":[0.9996998,0.000008903174,0.00003422642,0.0001686248,0.0000433575,0.00004503044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003478317,0.00001467934,0.001112043,0.0001019307,0.00007769023,0.0000136594,0.00006465609,0.0005104835,0.9415171,0.0007190693,0.000006259694,0.05582772],"study_design_scores_gemma":[0.0003097816,0.0001087545,0.007374361,0.0001733061,0.00002825092,0.000004647727,0.00005855035,0.003756547,0.9854142,0.001802193,0.0008017726,0.0001676367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733444,0.0185749,0.007336578,0.0003075413,0.0001006151,0.000161728,0.0000158876,0.000009640778,0.0001487313],"genre_scores_gemma":[0.9965187,0.002703934,0.0002686433,0.0002074532,0.00004463524,0.00003848053,0.0000112901,0.00002931502,0.0001775503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05566008,"threshold_uncertainty_score":0.4665841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166738695681074,"score_gpt":0.3223889909467752,"score_spread":0.3007216039899644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}