{"id":"W4399505157","doi":"10.1158/1538-8514.synthleth24-pr015","title":"Abstract PR015: Discovery of LY4050784 (FHD-909), a selective BRM (SMARCA2) ATPase inhibitor for the treatment of BRG1(SMARCA4) mutant cancers","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"SMARCA4; Chromatin remodeling; Cancer research; Mutant; Synthetic lethality; Cancer; Cell growth; Chemistry; Gene; Chromatin; Biology; Molecular biology; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003110773,0.0008372109,0.000501938,0.000475997,0.000172084,0.0005296493,0.0006876044,0.0007972114,0.003050901],"category_scores_gemma":[0.0001669895,0.0002244714,0.0004328697,0.0002764429,0.0002592359,0.0002993625,0.0003212071,0.001120467,0.001874955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005500069,"about_ca_system_score_gemma":0.0007776464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007600583,"about_ca_topic_score_gemma":0.001550228,"domain_scores_codex":[0.9998636,0.00001904128,0.00001081534,0.00002467302,0.00004695714,0.00003486016],"domain_scores_gemma":[0.9999237,0.000004526398,0.00001411787,0.000003261312,0.0000160093,0.00003849361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002450644,0.001545293,0.001229707,0.0008419576,0.0001698205,0.001337152,0.00007466473,0.001575264,0.836278,0.001779015,0.01337341,0.1393451],"study_design_scores_gemma":[0.01010379,0.04085172,0.01292436,0.0002463451,0.0004727228,0.008804131,0.0001264671,0.006739018,0.7537971,0.0008439424,0.1649606,0.0001297781],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8667727,0.05593913,0.0187917,0.004692309,0.001245865,0.002194219,0.00630937,0.00189975,0.04215498],"genre_scores_gemma":[0.9247748,0.02590433,0.008512447,0.00208993,0.0002138923,0.000435547,0.009140068,0.00007335941,0.02885576],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003050901,"threshold_uncertainty_score":0.01020628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01940260801772508,"score_gpt":0.300713497200709,"score_spread":0.2813108891829839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}