{"id":"W4399505157","doi":"10.1158/1538-8514.synthleth24-pr015","title":"Abstract PR015: Discovery of LY4050784 (FHD-909), a selective BRM (SMARCA2) ATPase inhibitor for the treatment of BRG1(SMARCA4) mutant cancers","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"SMARCA4; Chromatin remodeling; Cancer research; Mutant; Synthetic lethality; Cancer; Cell growth; Chemistry; Gene; Chromatin; Biology; Molecular biology; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001369574,0.0002959053,0.0003055222,0.00005190346,0.00007420144,0.00004082578,0.0002126746,0.0001691788,0.0000108125],"category_scores_gemma":[0.000009687828,0.0002116801,0.0004138961,0.0001883302,0.0001790395,0.000008283229,0.00003069716,0.00009626402,6.937072e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002782974,"about_ca_system_score_gemma":0.0008196741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005965412,"about_ca_topic_score_gemma":0.0003146238,"domain_scores_codex":[0.9985342,0.00003670808,0.0003967491,0.0004502257,0.0002627909,0.0003193139],"domain_scores_gemma":[0.999086,0.0000534699,0.0001567527,0.0004632654,0.0001913586,0.00004915179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003779506,0.0001530142,0.00007570811,0.0002284097,0.001263762,0.000006530229,0.0006304765,0.0042156,0.9426898,0.0001150119,0.0001892191,0.05005449],"study_design_scores_gemma":[0.0009611635,0.0008786478,0.0001645477,0.0001382158,0.0004037264,0.000006170386,0.0001651108,0.004159965,0.9482155,0.0001583901,0.04449088,0.0002576995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9121544,0.07374872,0.01136679,0.0003644847,0.0006014373,0.0009014598,0.0006731089,0.00002411914,0.0001654803],"genre_scores_gemma":[0.9886262,0.009817386,0.0002944048,0.0002104949,0.0003352872,0.0003116082,0.00006658799,0.00006755537,0.0002704427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07647182,"threshold_uncertainty_score":0.8632065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01940260801772508,"score_gpt":0.300713497200709,"score_spread":0.2813108891829839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}