{"id":"W4399505172","doi":"10.1158/1538-8514.synthleth24-pr007","title":"Abstract PR007: Delineating functional drivers of esophageal adenocarcinoma to identify synthetic lethal interactions","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CRISPR; Carcinogenesis; Biology; Synthetic lethality; Computational biology; Gene knockdown; Cancer research; Transcriptome; Gene; Genetics; DNA repair; Gene expression","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000290411,0.0004415961,0.0003994699,0.0008273523,0.0002149529,0.0004690818,0.0003523608,0.0004297501,0.003213767],"category_scores_gemma":[0.000260452,0.0002894717,0.0004905024,0.000418665,0.0002947086,0.00021902,0.0005202095,0.0007311368,0.001255685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625941,"about_ca_system_score_gemma":0.0004035646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008443053,"about_ca_topic_score_gemma":0.001504174,"domain_scores_codex":[0.9997064,0.00003022044,0.00003026183,0.00006594913,0.0001250231,0.00004204706],"domain_scores_gemma":[0.9997311,0.00006149802,0.00008761996,0.00003306804,0.0000335925,0.00005311111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004812029,0.00001161759,0.00057839,0.00003383041,0.000005825457,0.00007670469,0.000009154195,0.0001213168,0.9974866,0.0001051922,0.000050754,0.001472451],"study_design_scores_gemma":[0.0000104249,0.0001953701,0.01345492,0.000008015646,0.00003506169,0.001151783,0.00004824115,0.002741182,0.9772679,0.0001086319,0.004966029,0.00001241811],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9461193,0.001059242,0.04213042,0.0002540057,0.00004364345,0.0002035588,0.00578466,0.0007552545,0.003649899],"genre_scores_gemma":[0.948593,0.0008733902,0.03449349,0.0001753403,0.00001158432,0.0001440144,0.008410209,0.0003769221,0.006921999],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003213767,"threshold_uncertainty_score":0.01075113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05331619994262055,"score_gpt":0.3832789389001627,"score_spread":0.3299627389575422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}