{"id":"W4399505192","doi":"10.1158/1538-8514.synthleth24-b019","title":"Abstract B019: Stearoyl-CoA desaturase is a synthetic lethal target in SMAD4-deficient cancers","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Synthetic lethality; Cancer research; Biology; Mutant; Carcinogenesis; Fatty acid synthesis; CRISPR; In vivo; Cancer; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001910384,0.0005092499,0.000343999,0.0004991012,0.0002807825,0.0003639332,0.0002843512,0.0005543903,0.005477092],"category_scores_gemma":[0.0001396482,0.000211366,0.0004958021,0.0001963026,0.000310082,0.0001673569,0.0003684173,0.0009922212,0.001712407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003385593,"about_ca_system_score_gemma":0.0002857573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005938652,"about_ca_topic_score_gemma":0.0007578896,"domain_scores_codex":[0.9997546,0.00002830472,0.00002533765,0.00005024167,0.00009564382,0.00004576231],"domain_scores_gemma":[0.9998319,0.00002293544,0.00004687511,0.00001877795,0.00001897276,0.00006053665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001840482,0.00002804732,0.000146141,0.00003554692,0.000006253579,0.00007652475,0.000005665031,0.00004926793,0.9981912,0.00009765736,0.0001230938,0.001056564],"study_design_scores_gemma":[0.00002378285,0.0002588434,0.001321618,0.000007720983,0.00001612519,0.0003744885,0.00002357222,0.0003786298,0.9933839,0.00004406622,0.004162419,0.000004711131],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.968618,0.002322627,0.01410254,0.0006333994,0.0002886047,0.0001451841,0.005558688,0.0009950361,0.007335898],"genre_scores_gemma":[0.9723271,0.001314211,0.005457977,0.0002523759,0.00002667839,0.0001429695,0.004570894,0.0001759377,0.01573186],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005477092,"threshold_uncertainty_score":0.01832271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588855896612284,"score_gpt":0.2824860865792215,"score_spread":0.2665975276130987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}