{"id":"W4399505234","doi":"10.1158/1538-8514.synthleth24-ia023","title":"Abstract IA023: Targeting epigenetic complexes in leukemia","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epigenetics; Myeloid leukemia; Chromatin; Leukemia; Cancer research; Cancer; NPM1; Biology; Computational biology; Medicine; Bioinformatics; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002159781,0.000410969,0.000307342,0.0004906663,0.0002315078,0.0004549506,0.0004444206,0.0003704859,0.005766567],"category_scores_gemma":[0.0000792796,0.0001721352,0.0002347427,0.0003431732,0.000219431,0.0001562111,0.0003426929,0.0007290322,0.001290051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001063151,"about_ca_system_score_gemma":0.0008336758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003900284,"about_ca_topic_score_gemma":0.006776924,"domain_scores_codex":[0.9999267,0.000009511089,0.00000407778,0.00001208557,0.00002341363,0.0000243434],"domain_scores_gemma":[0.9999679,0.000002666085,0.000004570942,0.000003005689,0.000006935441,0.00001500601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001015203,0.0003226511,0.0003724425,0.0003936516,0.00002843662,0.0001993391,0.0000444697,0.001082339,0.9052408,0.003334195,0.01162965,0.0763367],"study_design_scores_gemma":[0.0007836561,0.002944817,0.005916918,0.00006015242,0.00009470851,0.0008758559,0.00003385846,0.003202544,0.7666433,0.000682293,0.2187344,0.0000275582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7319195,0.09972315,0.0302891,0.00709425,0.00223442,0.001560481,0.007984857,0.00359858,0.1155956],"genre_scores_gemma":[0.8677811,0.03663677,0.01484772,0.001657333,0.000320837,0.0003903974,0.00535016,0.0002218686,0.07279393],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005766567,"threshold_uncertainty_score":0.0192911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900543605627948,"score_gpt":0.2916555355123758,"score_spread":0.2726500994560964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}