{"id":"W4399505308","doi":"10.1158/1538-8514.synthleth24-b010","title":"Abstract B010: Drug tolerant persister cancer cells escape therapy-induced senescence","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University Health Centre; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"","keywords":"Autophagy; Medicine; Cancer; Cancer research; Senescence; Breast cancer; Cancer cell; Drug resistance; Chemotherapy; Oncology; Pharmacology; Internal medicine; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181178,0.0002917489,0.0003304421,0.0003412417,0.0004103287,0.0008202013,0.0002429983,0.0005039769,0.00597132],"category_scores_gemma":[0.0001522492,0.0001571039,0.0002454682,0.0002844743,0.0002902433,0.0003560187,0.0003332403,0.0008551283,0.002059185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004298778,"about_ca_system_score_gemma":0.0004416163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008895705,"about_ca_topic_score_gemma":0.0009275913,"domain_scores_codex":[0.9998726,0.000009270914,0.00001214856,0.00003426579,0.00005018457,0.00002155863],"domain_scores_gemma":[0.9998786,0.00001543004,0.0000261275,0.00001708497,0.00002623597,0.00003652323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000223181,0.00004106585,0.0006485679,0.00009030753,0.000006990798,0.0001525297,0.00004869167,0.00005655172,0.9882466,0.0005907593,0.002425704,0.007469126],"study_design_scores_gemma":[0.00008331588,0.001136225,0.02920445,0.00005453977,0.00004361501,0.002606558,0.0001949159,0.001470359,0.8769961,0.0008302158,0.08734538,0.00003439866],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9391195,0.01408576,0.01244069,0.002824347,0.001178917,0.0002447356,0.008503491,0.001052762,0.02054981],"genre_scores_gemma":[0.9116709,0.006182973,0.007179766,0.001085139,0.0001370453,0.0002226196,0.01031536,0.0002328819,0.06297326],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00597132,"threshold_uncertainty_score":0.01997602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04302251950577732,"score_gpt":0.3139448282089302,"score_spread":0.2709223087031529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}