{"id":"W4399505409","doi":"10.1158/1538-8514.synthleth24-pr006","title":"Abstract PR006: DNA repair inhibition via targeting ATR activates cGAS/STING signaling, promotes anti-tumor immunity, and is a synthetic lethal strategy to augment immunotherapy response in preclinical models and clinical samples of small cell lung cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; Blockade; Immunotherapy; Immune checkpoint; Tumor microenvironment; Biology; Immune system; Immunology; Medicine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508685,0.0005835454,0.0003096327,0.0002927738,0.0001431046,0.0002955539,0.0002841804,0.0003309633,0.00384119],"category_scores_gemma":[0.00007398383,0.0001030621,0.0003321568,0.000195657,0.0002510084,0.0001964687,0.0001584291,0.001402933,0.0007307557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002282848,"about_ca_system_score_gemma":0.0003302204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003133367,"about_ca_topic_score_gemma":0.0007229983,"domain_scores_codex":[0.9998842,0.00001434948,0.000008064581,0.00002497227,0.00004350966,0.0000248545],"domain_scores_gemma":[0.9999341,0.00000698704,0.00001968416,0.000007024629,0.000005984043,0.00002632364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004786064,0.0002395016,0.0001687278,0.00007242161,0.00001154728,0.00003780986,0.000006850291,0.0001524482,0.9931579,0.00008702062,0.0003838937,0.005203035],"study_design_scores_gemma":[0.0001294204,0.003274588,0.002569003,0.000009157048,0.00002863736,0.0002304703,0.00001273213,0.0008620236,0.989417,0.00004527298,0.003417159,0.000004493289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843424,0.00405488,0.004612308,0.0005237676,0.0001721509,0.0001372823,0.001483261,0.000518537,0.004155465],"genre_scores_gemma":[0.9854621,0.001790413,0.003314404,0.0001666451,0.0000506439,0.00009747057,0.001962369,0.00003786977,0.007118108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00384119,"threshold_uncertainty_score":0.01285005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08230421986962153,"score_gpt":0.4102955688589184,"score_spread":0.3279913489892968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}