{"id":"W4399505409","doi":"10.1158/1538-8514.synthleth24-pr006","title":"Abstract PR006: DNA repair inhibition via targeting ATR activates cGAS/STING signaling, promotes anti-tumor immunity, and is a synthetic lethal strategy to augment immunotherapy response in preclinical models and clinical samples of small cell lung cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; Blockade; Immunotherapy; Immune checkpoint; Tumor microenvironment; Biology; Immune system; Immunology; Medicine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002211318,0.0003718575,0.0007335773,0.000241283,0.0001171748,0.00008394298,0.0001276507,0.0001743558,0.00003978081],"category_scores_gemma":[0.0001313258,0.0003249058,0.0002080236,0.0003541196,0.0002891864,0.0001213926,0.0001907348,0.0007721049,5.470339e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003325206,"about_ca_system_score_gemma":0.0006475765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00148996,"about_ca_topic_score_gemma":0.00008322308,"domain_scores_codex":[0.9967875,0.0004802392,0.0009811708,0.0007437653,0.0004738151,0.0005335209],"domain_scores_gemma":[0.9981341,0.0009260354,0.000205502,0.0003617036,0.0002093664,0.000163297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003538018,0.0003742043,0.02422617,0.002072155,0.001109471,0.0002006385,0.004024426,0.001160504,0.9484078,0.00001119263,0.00002480089,0.01485057],"study_design_scores_gemma":[0.004816572,0.003659587,0.06268258,0.009789327,0.0009603772,0.0000452075,0.001280089,0.06390379,0.8506516,0.0008011381,0.0003962107,0.001013563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9405562,0.05482363,0.001254392,0.001645651,0.00009819044,0.001440697,0.00006707167,0.00009308617,0.00002106659],"genre_scores_gemma":[0.9920438,0.005258569,0.001742563,0.0005124824,0.00009298538,0.0002220878,0.000006929548,0.00009524375,0.00002533199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09775629,"threshold_uncertainty_score":0.9999203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08230421986962153,"score_gpt":0.4102955688589184,"score_spread":0.3279913489892968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}