{"id":"W4399510743","doi":"10.1096/fj.202400031r","title":"TRPV4 mediates IL ‐1‐induced Ca 2+ signaling, ERK activation and MMP expression","year":2024,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; MAPK/ERK pathway; Cell biology; Matrix metalloproteinase; Signal transduction; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726265,0.0004082701,0.0003009083,0.000249944,0.0002776609,0.0004386362,0.0002576249,0.0004967845,0.004920439],"category_scores_gemma":[0.0001717025,0.0001574744,0.0005721786,0.0002163441,0.0004183091,0.0003820686,0.0002793241,0.0009155545,0.0009491859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004550419,"about_ca_system_score_gemma":0.0003496085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00090658,"about_ca_topic_score_gemma":0.000842711,"domain_scores_codex":[0.9997354,0.00003010792,0.00001788383,0.00003999363,0.00007266087,0.0001039051],"domain_scores_gemma":[0.9998651,0.00002127447,0.00003876344,0.00001640255,0.0000208952,0.00003767681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001026776,0.00001110498,0.00005471928,0.00005824059,0.000003256075,0.00003653533,0.000006479532,0.00003181178,0.9993069,0.00008318682,0.00007293424,0.0002321274],"study_design_scores_gemma":[0.00004181287,0.0001715042,0.009455501,0.00001678615,0.00001601046,0.0004052594,0.0000630019,0.001255843,0.9854156,0.0001473864,0.003003378,0.000007826486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839707,0.002674932,0.006387912,0.0005567076,0.0001013514,0.00007260549,0.002196071,0.0001766348,0.003863069],"genre_scores_gemma":[0.9886274,0.0007376607,0.002302552,0.0001731901,0.00003441169,0.0001331107,0.002141357,0.00004322314,0.005807119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004920439,"threshold_uncertainty_score":0.01646054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02887722535378413,"score_gpt":0.2599952896010354,"score_spread":0.2311180642472512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}