{"id":"W4399510743","doi":"10.1096/fj.202400031r","title":"TRPV4 mediates IL ‐1‐induced Ca 2+ signaling, ERK activation and MMP expression","year":2024,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; MAPK/ERK pathway; Cell biology; Matrix metalloproteinase; Signal transduction; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","scholarly_communication","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.002705201,0.00129228,0.001045176,0.001035945,0.002482985,0.002002373,0.00172185,0.0008320116,0.0001096087],"category_scores_gemma":[0.008850701,0.000896515,0.0006632739,0.001667009,0.0006137519,0.001891836,0.0006618113,0.003431196,0.0006474735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000316664,"about_ca_system_score_gemma":0.0005395915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006103229,"about_ca_topic_score_gemma":0.000004818022,"domain_scores_codex":[0.9908332,0.001293142,0.001555083,0.001648484,0.002427242,0.002242877],"domain_scores_gemma":[0.9871203,0.00932125,0.001176593,0.0007739486,0.0003674248,0.001240484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006571519,0.000218048,0.0002229982,0.0001541299,0.0001055715,0.0002241144,0.01911575,0.003064782,0.8954813,0.0001887353,0.08000048,0.001217472],"study_design_scores_gemma":[0.001230812,0.0004871586,0.0001837061,0.0008482881,0.0001795667,0.0008993476,0.01394618,0.01367034,0.9231833,0.00222085,0.04302661,0.0001238847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871786,0.002053811,0.0009777914,0.0005787437,0.004105808,0.0009173913,0.0001863647,0.0004955364,0.003505972],"genre_scores_gemma":[0.9804783,0.002367905,0.000227459,0.001133233,0.004927011,0.00008388756,0.00005657898,0.0002934342,0.01043218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03697386,"threshold_uncertainty_score":0.9999829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02887722535378413,"score_gpt":0.2599952896010354,"score_spread":0.2311180642472512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}