{"id":"W4399512670","doi":"10.1093/genetics/iyae093","title":"SHC-3: a previously unidentified <i>C. elegans</i> Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest","year":2024,"lang":"en","type":"article","venue":"Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Genetics; Family member; Signal transduction; Caenorhabditis elegans; Mutation; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007276158,0.0005316647,0.0001605175,0.0003063561,0.0004106698,0.000289525,0.0003271308,0.0003647402,0.001156615],"category_scores_gemma":[0.00006475398,0.0001035299,0.0003359788,0.0001429475,0.0004687868,0.0002001947,0.0002844496,0.0005305727,0.0003865797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007629683,"about_ca_system_score_gemma":0.0005549854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002688544,"about_ca_topic_score_gemma":0.004524654,"domain_scores_codex":[0.9999367,0.00000264888,0.000004077762,0.00001993353,0.00001832813,0.0000183289],"domain_scores_gemma":[0.9999148,0.000006096436,0.00002215497,0.000006953099,0.00001195294,0.00003810901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000815801,0.0000127175,0.0004851826,0.0000325764,0.000003602178,0.00009905122,0.000009909803,0.00004074058,0.9977481,0.0001301133,0.0001068593,0.001249552],"study_design_scores_gemma":[0.00001963292,0.00009386838,0.02021032,0.00001624096,0.00002216675,0.0006555863,0.0000370532,0.001323755,0.9716894,0.0000948477,0.005822806,0.00001444633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917424,0.0006143926,0.003578374,0.0001695442,0.00004365016,0.00004068732,0.001585193,0.000249343,0.001976447],"genre_scores_gemma":[0.9879144,0.0003371066,0.005217717,0.00009333673,0.000009390435,0.0000451035,0.001614423,0.00006164311,0.004706953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002688544,"threshold_uncertainty_score":0.005535781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420198569080261,"score_gpt":0.2553468195479107,"score_spread":0.2411448338571081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}