{"id":"W4399520684","doi":"10.1212/wnl.0000000000209419","title":"Continuous β-Amyloid CSF/PET Imbalance Model to Capture Alzheimer Disease Heterogeneity","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; University College London Hospitals NHS Foundation Trust; Stockholms Läns Landsting; Eisai; Canadian Institutes of Health Research; Prothena; University of Southern California; University College London; European Federation of Pharmaceutical Industries and Associations; EU Joint Programme – Neurodegenerative Disease Research; Alzheimerfonden; Karolinska Institutet; ZonMw; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Grifols; F. Hoffmann-La Roche; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; European Commission; Sanofi; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Demensförbundet; Novartis Pharmaceuticals Corporation","keywords":"Alzheimer's disease; Amyloid (mycology); Medicine; Disease; Amyloid β; Neuroscience; Pathology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00637763,0.001326173,0.001351782,0.001207898,0.0004156572,0.001746135,0.002956294,0.001651255,0.002859614],"category_scores_gemma":[0.008753449,0.0006196119,0.002007866,0.0008094157,0.001331584,0.00116699,0.001397074,0.001800839,0.0005568789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001751,"about_ca_system_score_gemma":0.001318969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01018269,"about_ca_topic_score_gemma":0.004138658,"domain_scores_codex":[0.9977571,0.0009626631,0.00008717668,0.0007399681,0.0001672376,0.0002858331],"domain_scores_gemma":[0.9951153,0.003084977,0.0007772554,0.0003566747,0.0004872117,0.0001786527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00169569,0.0005148241,0.0996865,0.0002011995,0.001369248,0.0009366528,0.0006950126,0.8235907,0.004003139,0.02546783,0.00269099,0.03914823],"study_design_scores_gemma":[0.00007502335,0.000114952,0.005935065,0.00001902511,0.0001377307,0.00009718905,0.00003942948,0.9858344,0.0002393799,0.006983921,0.0005038081,0.00002011837],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5568067,0.001329846,0.4333762,0.002050115,0.0001579519,0.0003370839,0.002178137,0.0007885499,0.002975346],"genre_scores_gemma":[0.9754624,0.0001747648,0.0194313,0.0002169514,0.0000846175,0.0002791245,0.0008844296,0.00005418289,0.003412127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01018269,"threshold_uncertainty_score":0.0337286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02465648399266721,"score_gpt":0.32633927915175,"score_spread":0.3016827951590828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}