{"id":"W4399521570","doi":"10.6004/jnccn.2024.7042","title":"Optimizing Ovarian Cancer Treatment and Prevention Through Parallel Germline and Somatic Genetic Testing","year":2024,"lang":"en","type":"letter","venue":"Journal of the National Comprehensive Cancer Network","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Ovarian cancer; Medicine; Olaparib; Genetic testing; PARP inhibitor; Oncology; Germline; Cancer; BRCA mutation; Internal medicine; Germline mutation; Breast cancer; PALB2; Gynecology; Mutation; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001935418,0.000380525,0.0005653481,0.001135579,0.0003608731,0.0009275798,0.0005563052,0.0006293388,0.009331442],"category_scores_gemma":[0.006030123,0.0001754248,0.0006922206,0.0006342125,0.0002769193,0.0008705631,0.001175641,0.0009117702,0.001554789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008998009,"about_ca_system_score_gemma":0.002000634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004084307,"about_ca_topic_score_gemma":0.007040482,"domain_scores_codex":[0.9989526,0.0003814854,0.00005814659,0.0001195061,0.000375599,0.000112681],"domain_scores_gemma":[0.9984784,0.0005168511,0.0002871699,0.0001048268,0.000352187,0.0002605935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004199158,0.001163923,0.02611274,0.0006431422,0.0002365296,0.0004025431,0.0001136282,0.004702978,0.003532992,0.002164165,0.03025584,0.9302516],"study_design_scores_gemma":[0.00228728,0.008500348,0.291135,0.006272858,0.001614253,0.00934979,0.001392753,0.03018083,0.0170918,0.04492668,0.5870454,0.0002030097],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.3058939,0.2198804,0.1601427,0.1036432,0.003218697,0.005990363,0.004794831,0.005183071,0.1912528],"genre_scores_gemma":[0.7442364,0.08437686,0.1266492,0.02219886,0.00322331,0.001460123,0.002645756,0.000387573,0.01482194],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.009331442,"threshold_uncertainty_score":0.03121674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06058403225475431,"score_gpt":0.3355404807866882,"score_spread":0.2749564485319339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}