{"id":"W4399521570","doi":"10.6004/jnccn.2024.7042","title":"Optimizing Ovarian Cancer Treatment and Prevention Through Parallel Germline and Somatic Genetic Testing","year":2024,"lang":"en","type":"letter","venue":"Journal of the National Comprehensive Cancer Network","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Ovarian cancer; Medicine; Olaparib; Genetic testing; PARP inhibitor; Oncology; Germline; Cancer; BRCA mutation; Internal medicine; Germline mutation; Breast cancer; PALB2; Gynecology; Mutation; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009071229,0.000303992,0.0003499484,0.00005762621,0.0001852685,0.00009117726,0.0002054671,0.0003030951,0.00001826306],"category_scores_gemma":[0.00005520524,0.0002225498,0.0001627187,0.0001959278,0.0001252845,0.00001160363,0.0001553939,0.0005358683,6.525726e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000430086,"about_ca_system_score_gemma":0.000942066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003114483,"about_ca_topic_score_gemma":0.00002771226,"domain_scores_codex":[0.9983976,0.0001536706,0.0005179371,0.0003370591,0.0003569949,0.0002367074],"domain_scores_gemma":[0.9980934,0.0001344137,0.0006783339,0.0001467568,0.0009073327,0.00003976221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007005747,0.00001768635,0.0004527427,0.0002659749,0.001462323,0.00002044737,0.0002167624,0.2213877,0.002696255,0.00001299939,0.7684757,0.004921352],"study_design_scores_gemma":[0.001402512,0.0003758991,0.0034109,0.001726874,0.001032966,0.0006258059,0.00003731834,0.002783485,0.0004168747,0.008028583,0.9796584,0.0005003409],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.04974999,0.5344553,0.003300651,0.4031486,0.007154451,0.001452565,0.0003071429,0.00002473753,0.0004065306],"genre_scores_gemma":[0.06041308,0.07079624,0.1823748,0.5501787,0.1266554,0.0007800368,0.0002564728,0.0005158735,0.008029328],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4636591,"threshold_uncertainty_score":0.9075319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06058403225475431,"score_gpt":0.3355404807866882,"score_spread":0.2749564485319339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}