{"id":"W4399528845","doi":"10.3390/biomedicines12061289","title":"Defining the Role of Oral Pathway Inhibitors as Targeted Therapeutics in Arteriovenous Malformation Care","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Vascular Malformations Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network; University of Toronto","funders":"","keywords":"Medicine; Arteriovenous malformation; Druggability; Intensive care medicine; Genetic syndromes; Bioinformatics; Surgery; Pediatrics; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002039768,0.0004242993,0.0008335111,0.0007498293,0.0003424447,0.002200281,0.0006452156,0.00118251,0.005678778],"category_scores_gemma":[0.002374296,0.0001593206,0.0006736343,0.000415313,0.0006310101,0.002411546,0.001037069,0.002527885,0.001071948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001099417,"about_ca_system_score_gemma":0.00180923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009244807,"about_ca_topic_score_gemma":0.002736675,"domain_scores_codex":[0.999369,0.0002159061,0.00008985939,0.00007743615,0.0001705978,0.00007731808],"domain_scores_gemma":[0.9985641,0.0007035859,0.0002558123,0.00004808107,0.000299108,0.000129289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007212941,0.0002829972,0.001058763,0.003354897,0.0001354676,0.0005398869,0.0001509853,0.0007090213,0.006861324,0.02804085,0.01849569,0.9396489],"study_design_scores_gemma":[0.0004541733,0.002055528,0.003531965,0.00686465,0.0003390367,0.002735195,0.0003307181,0.001270704,0.006033828,0.02702716,0.9492916,0.00006544119],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007934762,0.9454563,0.004863339,0.02000688,0.001959909,0.00009136519,0.0001989547,0.00007725379,0.01941127],"genre_scores_gemma":[0.06767716,0.9038467,0.01040444,0.008408995,0.003095492,0.0002000658,0.0002942235,0.00005596659,0.006016913],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005678778,"threshold_uncertainty_score":0.01899737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007392819917290915,"score_gpt":0.2582178779380057,"score_spread":0.2508250580207148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}