{"id":"W4399529545","doi":"10.1073/pnas.2219137121","title":"Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"National Institute of Mental Health; Wellcome Trust","keywords":"Biology; Neuroscience; Cortex (anatomy); Human brain; PAX6; Cerebral cortex; Transcription factor; Anatomy; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002238588,0.0001540179,0.0002124198,0.0006893572,0.0001513023,0.0004020758,0.0001413817,0.0001731017,0.0006738985],"category_scores_gemma":[0.0006001742,0.00009175988,0.0002108957,0.0006707509,0.0003029078,0.0003029448,0.0002483854,0.0002016984,0.0002592892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653534,"about_ca_system_score_gemma":0.0002079904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129076,"about_ca_topic_score_gemma":0.005222085,"domain_scores_codex":[0.9998959,0.00001685909,0.000005877576,0.00004948068,0.00001767886,0.00001423585],"domain_scores_gemma":[0.9998298,0.00004874132,0.0000513782,0.00003767239,0.00001855279,0.00001385943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004093484,0.00006923286,0.3964649,0.0005151905,0.0005227487,0.0002949157,0.0004614017,0.01418946,0.4618881,0.003398779,0.003677926,0.118108],"study_design_scores_gemma":[0.000008376926,0.00003499325,0.9515401,0.00002422349,0.00008440232,0.0003609106,0.0001951605,0.01940452,0.01843507,0.00392706,0.005969038,0.00001621778],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778341,0.00150875,0.01258475,0.000133299,0.000005568016,0.00001151633,0.006525654,0.0001246153,0.001271652],"genre_scores_gemma":[0.9876773,0.0005708702,0.005962164,0.00004096875,0.000007507,0.0000288573,0.00528876,0.00004075995,0.0003827752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002129076,"threshold_uncertainty_score":0.00423336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03152262838974121,"score_gpt":0.3038920992164124,"score_spread":0.2723694708266712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}