{"id":"W4399533105","doi":"10.3390/ph17060763","title":"Emerging Perspectives on Prime Editor Delivery to the Brain","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; Université Laval","funders":"","keywords":"Nanomedicine; CRISPR; Prime (order theory); Cas9; Genome editing; Computer science; Medicine; Engineering ethics; Computational biology; Neuroscience; Nanotechnology; Bioinformatics; Psychology; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001580128,0.0007056802,0.0009243966,0.0008942189,0.0003954866,0.002445248,0.001013026,0.002193461,0.007015788],"category_scores_gemma":[0.001368779,0.0002326256,0.0005226072,0.0006185085,0.001165096,0.003086691,0.0009689351,0.002820086,0.002008993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006901352,"about_ca_system_score_gemma":0.001239885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000421164,"about_ca_topic_score_gemma":0.000742997,"domain_scores_codex":[0.9994911,0.0001129815,0.00004582221,0.0001207772,0.0001552889,0.0000740364],"domain_scores_gemma":[0.9989926,0.0005620922,0.0001046212,0.00003981049,0.0002051808,0.00009561569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006562318,0.0001941915,0.0008196664,0.0158444,0.0002069633,0.002022576,0.0005440959,0.001282805,0.08296918,0.08185107,0.05784343,0.7557654],"study_design_scores_gemma":[0.00003941411,0.0005557482,0.000611326,0.00129034,0.0001438949,0.003337973,0.0003553313,0.0007899039,0.03750315,0.02648166,0.9288284,0.0000629147],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003077793,0.9566826,0.01335828,0.01255631,0.002401081,0.00002434748,0.0001524278,0.0001909716,0.01155628],"genre_scores_gemma":[0.02686013,0.9545819,0.006182529,0.00440198,0.002690279,0.00005807311,0.0002359681,0.00005964148,0.004929494],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007015788,"threshold_uncertainty_score":0.02347016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465819921923009,"score_gpt":0.3877995127289977,"score_spread":0.3731413135097675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}